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PMID: 6324665 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasmid-mediated tetracycline resistance in Haemophilus ducreyi.

Antimicrobial agents and chemotherapy ·Vol. 25 ·No. 2 ·1984-02-00 ·Pages 187-90

Albritton WL, Maclean IW, Slaney LA, Ronald AR, Deneer HG

Abstract

Clinical isolates of Haemophilus ducreyi were shown to be resistant to tetracycline. Resistance was associated in some strains with a 30-megadalton plasmid capable of transferring resistance in conjugative matings with other strains of H. ducreyi and other species of Haemophilus. Restriction endonuclease digestion patterns suggest a relationship between H. ducreyi plasmids and other tetracycline resistance plasmids in Haemophilus. The presence of plasmid-mediated resistance to the tetracyclines limits the use of these agents for the treatment of chancroid.

MeSH Terms
Conjugation, Genetic DNA Restriction Enzymes DNA, Bacterial/analysis Haemophilus ducreyi/drug effects,genetics Hydrolysis Phenotype R Factors Tetracycline/pharmacology
Chemicals
DNA, Bacterial DNA Restriction Enzymes Tetracycline
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Albritton W L
Maclean I W
Slaney L A
Ronald A R
Deneer H G
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22 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.25.2.187
Published
1984-02-00
Pages
187-90
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC185471
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.25.2.187 PMC Full Text View journal details
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