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PMID: 6328046 Published · ppublish English Journal Article

Laboratory and wild-derived mice with multiple loci for production of xenotropic murine leukemia virus.

Journal of virology ·Vol. 51 ·No. 1 ·1984-07-00 ·Pages 77-80

Kozak CA, Hartley JW, Morse HC

Abstract

Mendelian segregation analysis was used to define genetic loci for the induction of infectious xenotropic murine leukemia virus in several laboratory and wild-derived mice. MA/My mice contain two loci for xenotropic virus inducibility, one of which, Bxv -1, is the only induction locus carried by five other inbred strains. The second, novel MA/My locus, designated Mxv -1, is unlinked to Bxv -1 and shows a lower efficiency of virus induction. The NZB mouse carries two induction loci; both are distinct from Bxv -1 since neither is linked to the Pep-3 locus on chromosome 1. Finally, one partially inbred strain derived from the wild Japanese mouse, Mus musculus molossinus, carries multiple (at least three) unlinked loci for induction of xenotropic virus. Although it is probable that inbred strains inherited xenotropic virus inducibility from Japanese mice, our data suggest that none of the induction loci carried by this particular M. m. molossinus strain are allelic with Bxv -1.

MeSH Terms
Alleles Animals Chromosome Mapping Female Genetic Linkage Leukemia Virus, Murine Male Mice/genetics Mice, Inbred Strains/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kozak C A
Hartley J W
Morse H C
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.51.1.77-80.1984
Published
1984-07-00
Pages
77-80
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254402
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.51.1.77-80.1984 PMC Full Text View journal details
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