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PMID: 6330535 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Differential phosphorylation of MAP-2 stimulated by calcium-calmodulin and cyclic AMP.

Molecular and cellular biology ·Vol. 4 ·No. 6 ·1984-06-00 ·Pages 1175-8

Schulman H

Abstract

Comparison of cyclic AMP- and calcium-dependent phosphorylation in rat brain cytosol reveals MAP-2 to be a common endogenous substrate. Examination of limited protease digestion patterns indicates that the two kinases phosphorylate MAP-2 at distinct sites and suggests that such phosphorylation may have differential effects on MAP-2 function.

MeSH Terms
Animals Brain/metabolism Calcium/pharmacology Calmodulin/pharmacology Cyclic AMP/pharmacology Cytosol/metabolism Kinetics Male Microtubule-Associated Proteins Molecular Weight Nerve Tissue Proteins/metabolism Phosphorylation Protein Kinases/metabolism Proteins/metabolism Rats Rats, Inbred Strains
Chemicals
Calmodulin Microtubule-Associated Proteins Nerve Tissue Proteins Proteins Cyclic AMP Protein Kinases Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Schulman H
References (29)
29 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.4.6.1175-1178.1984
Published
1984-06-00
Pages
1175-8
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368889
Subset
IM
Grants
NIGMS NIH HHS · GM30179 · United States
NCRR NIH HHS · RR5353 · United States
External Links
PubMed source DOI: 10.1128/mcb.4.6.1175-1178.1984 PMC Full Text View journal details
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