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PMID: 6344015 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A nucleotide change in the anticodon of an Escherichia coli serine transfer RNA results in supD-amber suppression.

Nucleic acids research ·Vol. 11 ·No. 11 ·1983-06-11 ·Pages 3823-32

Steege DA

Abstract

The tRNAs specified by the wild type and amber suppressor alleles of the Escherichia coli supD gene have been identified, and their primary structures determined. The sequences differ by a single nucleotide in the middle of the anticodon. A CUA anticodon allows the suppressor tRNA to read the UAG stop codon; the CGA anticodon in the minor serine tRNA species from which the suppressor is derived is specific for the serine codon UCG.

MeSH Terms
Alleles Anticodon/genetics Base Sequence Codon/genetics Escherichia coli/genetics Mutation Nucleic Acid Conformation RNA, Transfer/genetics RNA, Transfer, Amino Acyl/genetics Suppression, Genetic
Chemicals
Anticodon Codon RNA, Transfer, Amino Acyl RNA, Transfer
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Steege D A
References (33)
33 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.11.3823
Published
1983-06-11
Pages
3823-32
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326005
Subset
IM
Grants
NIAID NIH HHS · AI-14882 · United States
NCI NIH HHS · CA-14236 · United States
Databases
GENBANK
K03318, X01580
External Links
PubMed source DOI: 10.1093/nar/11.11.3823 PMC Full Text View journal details
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