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PMID: 6348703 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular basis for modulated regulation of gene expression in the arginine regulon of Escherichia coli K-12.

Nucleic acids research ·Vol. 11 ·No. 15 ·1983-08-11 ·Pages 5007-19

Cunin R, Eckhardt T, Piette J, Boyen A, Piérard A, Glansdorff N

Abstract

We compare the nucleotide sequences of the regulatory regions of five genes or groups of genes of the arginine regulon of Escherichia coli K-12: argF, argI, argR, the bipolar argECBH operon and the carAB operon. All these regions harbour one or two copies of a conserved 18 bp sequence which appears to constitute the basic arginine operator sequence (ARG box). We discuss the influence of ARG box copy number, degree of dyad symmetry, base composition, and position relative to the cognate promoter site on the derepression-repression ratios of the genes of the regulon. A novel hypothesis, based on structural considerations, is also put forward to account for the absence ot attenuation control.

MeSH Terms
Arginine/biosynthesis,genetics Base Sequence Escherichia coli/genetics Genes Genes, Bacterial Genes, Regulator Operon Transcription, Genetic
Chemicals
Arginine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Cunin R
Eckhardt T
Piette J
Boyen A
Piérard A
Glansdorff N
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37 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.15.5007
Published
1983-08-11
Pages
5007-19
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326233
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/11.15.5007 PMC Full Text View journal details
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