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PMID: 6357783 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice.

The EMBO journal ·Vol. 2 ·No. 5 ·1983-00-00 ·Pages 675-8

Panthier JJ, Rougeon F

Abstract

Two distinct phenotypic groups of inbred strains of mice, with different amounts of submaxillary gland (SMG) renin have been described. We have previously shown that strains with high levels of SMG renin, such as Swiss or AKR mice, have two renin genes, Rn1 and Rn2, per haploid genome, while strains with low levels of SMG, such as BALB/c or C57Bl/6, have only one renin gene. We now report the molecular cloning of cDNA copies of Swiss mouse kidney renin mRNA and present nucleotide sequence data of the recombinant clones. Comparison of these sequences with the sequence of Swiss mouse SMG renin mRNA we have previously reported, demonstrates that Swiss mice express the two non-allelic genes, Rn1 and Rn2.

MeSH Terms
Alleles Animals Base Sequence DNA/analysis Kidney/analysis Mice Mice, Inbred Strains Phenotype RNA, Messenger/analysis Renin/genetics Submandibular Gland/analysis
Chemicals
RNA, Messenger DNA Renin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Panthier J J
Rougeon F
References (23)
23 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1983-00-00
Pages
675-8
Language
English
Region
England
NLM ID
8208664
PMCID
PMC555168
Subset
IM
Databases
GENBANK
J00621, V00845
External Links
PubMed source PMC Full Text View journal details
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