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PMID: 6358035 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin.

Infection and immunity ·Vol. 42 ·No. 2 ·1983-11-00 ·Pages 838-41

Klipstein FA, Engert RF, Houghten RA

Abstract

Klebsiella pneumoniae heat-stable enterotoxin was purified to apparent homogenicity by the same techniques used to purify Escherichia coli heat-stable enterotoxin. The two toxins had the same potency in the suckling mouse assay and showed immunological cross-reactivity in enzyme-linked immunosorbent assay, neutralization of secretory activity by specific hyperimmune antisera, and protection against active challenge in rats immunized with a vaccine containing synthetically produced E. coli heat-stable enterotoxin.

MeSH Terms
Animals Antigen-Antibody Complex Biological Assay Drug Stability Enterotoxins/immunology,toxicity Hot Temperature Immune Sera Klebsiella pneumoniae/immunology Mice Rats Rats, Inbred Strains
Chemicals
Antigen-Antibody Complex Enterotoxins Immune Sera
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Klipstein F A
Engert R F
Houghten R A
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24 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.42.2.838-841.1983
Published
1983-11-00
Pages
838-41
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC264507
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.42.2.838-841.1983 PMC Full Text View journal details
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