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PMID: 6359892 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The immunochemical characterization of mesangial IgA deposits.

The American journal of pathology ·Vol. 113 ·No. 3 ·1983-12-00 ·Pages 359-64

Lomax-Smith JD, Zabrowarny LA, Howarth GS, Seymour AE, Woodroffe AJ

Abstract

Mesangial deposits of IgA are found in IgA nephropathy, Schönlein-Henoch purpura (SHP) and in some patients with alcoholic cirrhosis and systemic lupus erythematosus (SLE). In this study the authors characterized the mesangial IgA deposits in patients with the above diseases using antiserums or monoclonal antibodies to A1, A2, J-chain and secretory component (SC), and examined SC binding in vitro. SC was not present, J-chain was ubiquitous, and A2 was found (with the use of monoclonal antibodies) rarely but with equal frequency in all groups. The SC binding capacity of the deposits differed between the groups and was found in 13 of 16 patients with alcoholic liver disease, 3 of 4 with SLE, 1 of 10 with primary IgA nephropathy, and none of 6 with SHP.

MeSH Terms
Antibodies, Monoclonal/immunology Fluorescent Antibody Technique Glomerular Mesangium/immunology Humans IgA Vasculitis/immunology Immune Sera/immunology Immunoglobulin A/analysis Liver Cirrhosis, Alcoholic/complications Lupus Erythematosus, Systemic/immunology Nephritis/immunology
Chemicals
Antibodies, Monoclonal Immune Sera Immunoglobulin A
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lomax-Smith J D
Zabrowarny L A
Howarth G S
Seymour A E
Woodroffe A J
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21 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1983-12-00
Pages
359-64
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1916361
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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