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PMID: 6418373 Published · ppublish English Comparative Study Journal Article

Kaposi's sarcoma in renal transplant recipients. Ultrastructural and immunoperoxidase study of four cases.

Cancer ·Vol. 53 ·No. 2 ·1984-01-15 ·Pages 258-66

Akhtar M, Bunuan H, Ali MA, Godwin JT

Abstract

Tissues from four cases of Kaposi's sarcoma developing in renal transplant recipients were studied by light and electron microscopic examination and by immunoperoxidase staining for Factor-VIII-related antigen. Ultrastructurally, the tumors in all four cases contained a variable mixture of cells, including endothelial cells, pericytes, fibroblasts, and myofibroblasts. These findings support the origin of Kaposi's sarcoma from primitive vasoformative mesenchyme. Immunoperoxidase staining for Factor-VIII-related antigen was limited to endothelial cells. In one case intracytoplasmic virus-like tubular complexes were seen. The significance of this finding is briefly discussed.

MeSH Terms
Adult Antigens/analysis Biopsy Extremities Factor VIII/analysis Female Histocytochemistry Humans Immunoenzyme Techniques Kidney Transplantation Male Middle Aged Sarcoma, Kaposi/complications,ultrastructure Schwann Cells/ultrastructure
Chemicals
Antigens Factor VIII
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Akhtar M
Bunuan H
Ali M A
Godwin J T
References (24)
24 references, click to expand
  1. Intracellular branched tubular structures in osteosarcoma. An ultrastructural and serological study.
    Cancer. 1971 Jun;27(6):1440-8 PMID: 4932474
  2. THE FINE STRUCTURE OF THE SPINDLE CELL IN KAPOSI'S SARCOMA.
    Acta Pathol Microbiol Scand. 1965;63:567-75 PMID: 14324664
  3. Electron microscopic studies of coronavirus.
    J Gen Virol. 1971 Aug;12(2):161-8 PMID: 4107843
  4. Myofibroblasts in human granulation tissue.
    Hum Pathol. 1974 Jan;5(1):55-67 PMID: 4588257
  5. Kaposi's sarcoma in recipients of renal transplants.
    Am J Med. 1979 Nov;67(5):759-65 PMID: 159624
  6. KAPOSI'S SARCOMA. HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES.
    J Invest Dermatol. 1964 Dec;43:539-49 PMID: 14234860
  7. Significance of tubuloreticular inclusions in the pathobiology of human diseases.
    Pathobiol Annu. 1976;6:221-57 PMID: 798160
  8. The ultrastructure of Kaposi's sarcoma.
    Arch Ital Patol Clin Tumori. 1970 Jan-Jun;13(1):79-89 PMID: 5502809
  9. Tubular complexes of endoplasmic reticulum in lymphoblastic lymphoma: case report.
    Cancer. 1982 Apr 15;49(8):1629-35 PMID: 6978174
  10. Localization of factor VIII-related antigen in vascular endothelial cells using an immunoperoxidase method.
    Am J Surg Pathol. 1980 Jun;4(3):273-6 PMID: 6772042
  11. Electron microscope observations of Kaposi's sarcoma.
    Acta Derm Venereol. 1966;46(2):195-200 PMID: 4162640
  12. An electron-microscope study of kaposi's haemangiosarcoma.
    J Pathol Bacteriol. 1962 Apr;83:521-5 PMID: 14485165
  13. St. Louis encephalitis virus infection in mice. Electron microscopic studies of central nervous system.
    Lab Invest. 1968 Dec;19(6):652-62 PMID: 4974186
  14. Induction of tubuloreticular inclusions in human lymphoma cells (Raji line) related to S-phase treatment with halogenated pyrimidines.
    Cancer Res. 1977 Jul;37(7 Pt 1):2105-13 PMID: 861937
  15. Kaposi's sarcoma in organ transplant recipients: report of 20 cases.
    Transplantation. 1979 Jan;27(1):8-11 PMID: 442191
  16. Tubular complexes of endoplasmic reticulum in myeloblasts of acute myelogenous leukemia.
    Ultrastruct Pathol. 1980 Jan-Mar;1(1):55-65 PMID: 6940315
  17. Kaposi's sarcoma: immunohistologic evidence for an endothelial origin.
    Arch Pathol Lab Med. 1981 May;105(5):274-5 PMID: 6784701
  18. Vinblastine-induced aggregates of smooth endoplasmic reticulum in proximal tubular cells of rat kidney.
    Am J Anat. 1974 Jun;140(2):201-11 PMID: 4363602
  19. Dupuytren's contracture: fibroblast contraction? An ultrastructural study.
    Am J Pathol. 1972 Jan;66(1):131-46 PMID: 5009249
  20. Cytoplasmic microtubular structures in metastatic melanoma.
    Arch Pathol Lab Med. 1979 Sep;103(10):543 PMID: 582373
  21. Myogenic cells in Kaposi's sarcoma: an ultrastructural study.
    J Pathol. 1978 Mar;124(3):157-60 PMID: 363990
  22. Myofibroblasts and related cells in malignant fibrous and fibrohistiocytic tumors.
    Hum Pathol. 1977 Mar;8(2):205-18 PMID: 192657
  23. Cytoplasmic tubular arrays in cells of American Burkitt's type lymphoma.
    Cancer. 1976 Jan;37(1):275-84 PMID: 174797
  24. Fine structure of granulation tissue from deep injury.
    J Invest Dermatol. 1979 Apr;72(4):147-52 PMID: 429795
Article Info
Journal
Cancer
Abbr.
Cancer
ISSN
0008-543X
DOI
10.1002/1097-0142(19840115)53:2<258::aid-cncr2820530213>3.0.co;2-9
Published
1984-01-15
Pages
258-66
Language
English
Region
United States
NLM ID
0374236
PMCID
PMC7162315
Subset
IM
External Links
PubMed source DOI: 10.1002/1097-0142(19840115)53:2<258::aid-cncr2820530213>3.0.co;2-9 PMC Full Text View journal details
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