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PMID: 6978174 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Tubular complexes of endoplasmic reticulum in lymphoblastic lymphoma: case report.

Cancer ·Vol. 49 ·No. 8 ·1982-04-15 ·Pages 1629-35

Chu H, Foucar K, Barlogie B, Middleman E

Abstract

Distinctive intracytoplasmic tubular complexes have been identified occasionally by electron microscopy in a wide variety of hematologic and nonhematologic disorders. The mechanism of induction and significance of these tubular complexes are unknown. Tubular complexes were identified in the majority of bone marrow lymphoma-leukemia cells in a patient with documented lymphoblastic lymphoma in lymph node. These complexes varied in size but in general ranged from 800--1500 nm, and consisted of masses of nonparallel, twisted, smooth, 40-nm tubules. Continuity with adjacent endoplasmic reticulum was evident in some of the complexes. Cytochemical characteristics of the malignant cells included strong, focal, paranuclear acid phosphatase reactivity and strong, stippled nuclear terminal deoxynucleotidyl transferase positivity. Flow cytometric analysis showed a DNA-RNA content pattern consistent with acute lymphoblastic leukemia and typical of T-cell lymphoma. This represents the first report of such tubular complexes in a presumed T-cell malignancy.

MeSH Terms
Acid Phosphatase/analysis Adult Bone Marrow/enzymology,ultrastructure Cell Nucleus/enzymology DNA Nucleotidylexotransferase/analysis Endoplasmic Reticulum/ultrastructure Flow Cytometry Histocytochemistry Humans Lymph Nodes/enzymology,ultrastructure Lymphoma, Non-Hodgkin/enzymology,pathology,ultrastructure Male Microscopy, Electron T-Lymphocytes/ultrastructure
Chemicals
DNA Nucleotidylexotransferase Acid Phosphatase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chu H
Foucar K
Barlogie B
Middleman E
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31 references, click to expand
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Article Info
Journal
Cancer
Abbr.
Cancer
ISSN
0008-543X
DOI
10.1002/1097-0142(19820415)49:8<1629::aid-cncr2820490817>3.0.co;2-#
Published
1982-04-15
Pages
1629-35
Language
English
Region
United States
NLM ID
0374236
PMCID
PMC7162261
Subset
IM
Grants
NCI NIH HHS · CA-28771 · United States
External Links
PubMed source DOI: 10.1002/1097-0142(19820415)49:8<1629::aid-cncr2820490817>3.0.co;2-# PMC Full Text View journal details
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