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PMID: 6425268 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

New chloramphenicol resistance locus in Bacillus subtilis.

Journal of bacteriology ·Vol. 158 ·No. 1 ·1984-04-00 ·Pages 386-8

Anderson LM, Henkin TM, Chambliss GH, Bott KF

Abstract

A spontaneously occurring, noninducible, chloramphenicol-resistant mutant of Bacillus subtilis 168 has a mutation (cam-2) which maps in the ribosomal protein region of the chromosome near dal. Its presence does not confer dependence on chloramphenicol. Ribosomes of the cam-2 strain remained sensitive to chloramphenicol in in vitro protein synthesis. No chloramphenicol acetyltransferase activity could be detected.

MeSH Terms
Acetyltransferases/metabolism Bacillus subtilis/drug effects,enzymology,genetics Bacterial Proteins/analysis Chloramphenicol/pharmacology Chloramphenicol O-Acetyltransferase Chromosome Mapping Chromosomes, Bacterial Drug Resistance, Microbial Genes, Bacterial Mutation Ribosomal Proteins/analysis Ribosomes/drug effects
Chemicals
Bacterial Proteins Ribosomal Proteins Chloramphenicol Acetyltransferases Chloramphenicol O-Acetyltransferase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Anderson L M
Henkin T M
Chambliss G H
Bott K F
References (8)
8 references, click to expand
  1. Separation and radioautography of microgram quantities of ribosomal proteins by two-dimensional polyacrylamide gel electrophoresis.
    FEBS Lett. 1973 Jan 15;29(2):177-80 PMID: 4578220
  2. Chloramphenicol resistant mutants of Bacillus subtilis.
    Mol Gen Genet. 1973 Dec 20;127(2):163-73 PMID: 4203932
  3. Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria.
    Methods Enzymol. 1975;43:737-55 PMID: 1094240
  4. Construction of a kit of reference strains for rapid genetic mapping in Bacillus subtilis 168.
    Appl Environ Microbiol. 1977 Apr;33(4):989-93 PMID: 405929
  5. Mapping a cloned gene under sporulation control by inserttion of a drug resistance marker into the Bacillus subtilis chromosome.
    J Bacteriol. 1980 Apr;142(1):90-8 PMID: 6768719
  6. Studies of ribosomal proteins of yeast species and their hybrids: gel electrophoresis and immunochemical cross-reactions.
    Mol Gen Genet. 1980;179(2):273-82 PMID: 7007807
  7. Genetic mapping of a linked cluster of ribosomal ribonucleic acid genes in Bacillus subtilis.
    J Bacteriol. 1981 Nov;148(2):624-8 PMID: 6795182
  8. Bacterial in vitro protein-synthesizing systems.
    Methods Enzymol. 1983;101:598-605 PMID: 6193398
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.158.1.386-388.1984
Published
1984-04-00
Pages
386-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC215433
Subset
IM
Grants
NIGMS NIH HHS · GM07092 · United States
NIGMS NIH HHS · GM26399 · United States
NIGMS NIH HHS · GM32199 · United States
External Links
PubMed source DOI: 10.1128/jb.158.1.386-388.1984 PMC Full Text View journal details
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