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PMID: 6440122 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunoglobulin genes of different subgroups are interdigitated within the VK locus.

Nucleic acids research ·Vol. 12 ·No. 24 ·1984-12-21 ·Pages 9229-36

Pech M, Zachau HG

Abstract

The variable regions of immunoglobulins are encoded by multigene families which are rearranged during B-cell differentiation. These families were classified in groups and subgroups based on their amino acid sequences. Genes belonging to a distinct subgroup are believed to occur in the genome within clusters. We are investigating the organization of human variable region genes of the kappa type (VK genes, ref. 1) in the germline and found now for the first time that VK sequences of three of the four different subgroups are interdigitated within the VK locus. We present evidence for the interspersion of two VKIII genes and a VKII pseudogene within an array of five VKI genes. All eight VK sequences are arranged in the same orientation. An evolutionary model for the generation of this 'mixed cluster' is discussed.

MeSH Terms
Biological Evolution Chromosome Mapping Genetic Linkage Humans Immunoglobulin Light Chains/genetics Immunoglobulin Variable Region/genetics Immunoglobulin kappa-Chains/genetics
Chemicals
Immunoglobulin Light Chains Immunoglobulin Variable Region Immunoglobulin kappa-Chains
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pech M
Zachau H G
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30 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.24.9229
Published
1984-12-21
Pages
9229-36
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320456
Subset
IM
Databases
GENBANK
K02768, K02769
External Links
PubMed source DOI: 10.1093/nar/12.24.9229 PMC Full Text View journal details
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