Home LiteratureArticle Details
PMID: 6454748 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target.

The Journal of experimental medicine ·Vol. 153 ·No. 6 ·1981-06-01 ·Pages 1415-25

Sy MS, Nisonoff A, Germain RN, Benacerraf B, Greene MI

Abstract

The suppressor pathway that regulates the T cell response to p-azobenzenearsonate (ABA)-coupled cells has been studied. It has been found that the ability of anti-idiotypic second-order T suppressor cells (Ts2) to inhibit T cell-dependent delayed-type hypersensitivity (DTH) responses depended upon the presence of cross-reactive-idiotype (CRI)-bearing T cells present in ABA-primed mice. This suppressor T cell subset, termed Ts2, so exists with CRI-negative T cells that mediate DTH in vivo. It appears that antigen-activated CRI+ Ts3 require signals from the anti-CRI Ts2 subset to suppress DTH reactions in an idiotype-nonspecific manner. The relevance of these observations to a comprehensive scheme of T and B cell regulation is discussed.

MeSH Terms
Animals Cross Reactions Female Hypersensitivity, Delayed/immunology Immune Tolerance Immunity, Cellular Immunoglobulin Idiotypes Immunologic Memory Lymph Nodes/immunology Mice T-Lymphocytes/immunology T-Lymphocytes, Regulatory/immunology p-Azobenzenearsonate/immunology
Chemicals
Immunoglobulin Idiotypes p-Azobenzenearsonate
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sy M S
Nisonoff A
Germain R N
Benacerraf B
Greene M I
References (24)
24 references, click to expand
  1. Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains.
    J Exp Med. 1972 Mar 1;135(3):579-95 PMID: 4110016
  2. Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells.
    J Exp Med. 1972 Apr 1;135(4):764-79 PMID: 4401604
  3. Synergy during in vitro cytotoxic allograft responses. I. Evidence for cell interaction between thymocytes and peripheral T cells.
    J Exp Med. 1973 Dec 1;138(6):1379-97 PMID: 4543455
  4. Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity.
    Nature. 1974 Jun 14;249(458):654-6 PMID: 4275846
  5. T-T interaction in the generation of helper cells in vitro.
    Nature. 1975 Aug 28;256(5520):741-3 PMID: 50566
  6. Lymphoid cell subpopulations. I. Synergy between lymph node cells and thymocytes in response to alloantigens and mitogens.
    J Immunol. 1975 Nov;115(5):1227-32 PMID: 51885
  7. Presence on idiotype-specific suppressor T cells of receptors that interact with molecules bearing the idiotype.
    J Exp Med. 1977 Jun 1;145(6):1559-66 PMID: 325170
  8. Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide.
    J Immunol. 1977 Jul;119(1):240-4 PMID: 68972
  9. Mechanisms of regulation of cell-mediated immunity. II. Induction and suppression of delayed-type hypersensitivity to azobenzenearsonate-coupled syngeneic cells.
    J Immunol. 1978 Oct;121(4):1460-8 PMID: 81235
  10. Active suppression of 1-fluoro-2,4-dinitrobenzene-immune T cells. Requirement of an auxiliary T cell induced by antigen.
    J Exp Med. 1979 May 1;149(5):1197-207 PMID: 87487
  11. Binding of ovalbumin to mouse spleen cells with and without carbodiimide.
    J Immunol Methods. 1979;28(3-4):361-8 PMID: 479609
  12. Antigen- and receptor-driven regulatory mechanisms. II. Induction of suppressor T cells with idiotype-coupled syngeneic spleen cells.
    J Exp Med. 1979 Nov 1;150(5):1229-40 PMID: 91657
  13. Hypothesis. T-cell tolerance--one signal?
    Cell Immunol. 1979 Nov;48(1):201-7 PMID: 315830
  14. Antigen- and receptor-driven regulatory mechanisms. III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies.
    J Exp Med. 1980 Apr 1;151(4):896-909 PMID: 6445395
  15. Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.
    J Exp Med. 1980 May 1;151(5):1183-95 PMID: 6445398
  16. Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.
    J Exp Med. 1980 May 1;151(5):1213-31 PMID: 6966320
  17. Direct evidence for a two-signal mechanism of cytotoxic T-lymphocyte activation.
    Nature. 1980 May 15;285(5761):163-5 PMID: 6966377
  18. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway.
    J Exp Med. 1980 Jul 1;152(1):161-9 PMID: 6156980
  19. Antigen and receptor-driven regulatory mechanisms. VI. Demonstration of cross-reactive idiotypic determinants on azobenzenearsonate-specific antigen-binding suppressor T cells producing soluble suppressor factor(s).
    J Immunol. 1980 Dec;125(6):2374-9 PMID: 6159408
  20. Antigen- and receptor-driven regulatory mechanisms. V. The failure of idiotype-coupled spleen cells to induce unresponsiveness in animals lacking the appropriate VH genes is caused by the lack of idiotype-matched targets.
    J Exp Med. 1980 Nov 1;152(5):1226-35 PMID: 6159446
  21. A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression.
    Scand J Immunol. 1981;13(1):1-10 PMID: 6972088
  22. Mechanisms of regulation of cell-mediated immunity. VII. Suppressor T cells induced by suboptimal doses of antigen plus an I-J-specific allogeneic effect.
    J Exp Med. 1981 Feb 1;153(2):437-49 PMID: 6165798
  23. Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells.
    J Exp Med. 1981 Feb 1;153(2):450-63 PMID: 6165799
  24. Enhancement of dinitrochlorobenzene (DNCB) contact sensitization by cyclophosphamide in the guinea pig.
    J Invest Dermatol. 1967 Jan;48(1):39-43 PMID: 6018241
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.153.6.1415
Published
1981-06-01
Pages
1415-25
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186180
Subset
IM
Grants
NIAID NIH HHS · AI-12907 · United States
NIAID NIH HHS · AI-14732 · United States
NIAID NIH HHS · AI-16396 · United States
External Links
PubMed source DOI: 10.1084/jem.153.6.1415 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2