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PMID: 6966320 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.

The Journal of experimental medicine ·Vol. 151 ·No. 5 ·1980-05-01 ·Pages 1213-31

Hirai Y, Nisonoff A

Abstract

Evidence is presented for the selective suppression of the major idiotypic component of the humoral response to the phenylarsonate hapten by soluble factors derived from T cells (TsF). The existence of TsF with anti-idiotypic receptors was also demonstrated. It was found that TsF with idiotypic and anti-idiotypic receptors coexist in cultures of spleen cells prepared from idiotypically suppressed, hyperimmunized mice. By gel filtration the molecular weight of each factor was found to be 50,000-100,000. Each is sensitive to trypsin and is bound to a column containing anti-H-2a antibodies. Evidence is discussed which suggests the possibility of mutual stimulation of suppressor T cells with idiotypic and anti-idiotypic receptors.

MeSH Terms
Animals Antibody Formation Binding Sites Cells, Cultured Dose-Response Relationship, Immunologic H-2 Antigens/analysis Haptens Immune Tolerance Immunoglobulin Idiotypes Lymphokines/immunology Mice Receptors, Immunologic Spleen/immunology T-Lymphocytes/immunology
Chemicals
H-2 Antigens Haptens Immunoglobulin Idiotypes Lymphokines Receptors, Immunologic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hirai Y
Nisonoff A
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54 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.151.5.1213
Published
1980-05-01
Pages
1213-31
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185863
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.151.5.1213 PMC Full Text View journal details
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