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PMID: 309912 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice.

The Journal of experimental medicine ·Vol. 148 ·No. 5 ·1978-11-01 ·Pages 1216-27

Bottomly K, Mathieson BJ, Mosier DE

Abstract

An adoptive secondary antibody response to phosphorylcholine (PC) can be generated by the transfer of keyhole limpet hemocyanin (KLH)-primed T cells, PC-bovine gamma globulin-primed B cells, and PC-KLH into irradiated syngeneic BALB/c mice. If the KLH-primed T-cell donors were pretreated with anti-idiotype antibodies directed against the BALB/c PC-binding myeloma TEPC 15, their T cells were unable to collaborate effectively with PC-primed B cells; moreover, they could suppress the helper activity of T cells from normal mice for the PC-KLH response. The Ly phenotype of these T cells was found to be Ly 1-, 2+. The specificity of the suppressor T-cell population induced by anti-T15 treatment appears to be both for idiotype (hapten) and carrier, since the suppressor T cells fail to interfere with the antibody response to PC on a heterologous carrier, nor do they suppress the response to trinitrophenol-KLH.

MeSH Terms

Animals Antibodies, Anti-Idiotypic Antigens, Surface/analysis B-Lymphocytes/immunology Choline/analogs & derivatives Hemocyanins/immunology Immunoglobulin Idiotypes Immunologic Memory Immunosuppression Therapy Lymphocyte Cooperation Mice Mice, Inbred BALB C Phenotype Phosphorylcholine/immunology T-Lymphocytes/immunology

Chemicals

Antibodies, Anti-Idiotypic Antigens, Surface Immunoglobulin Idiotypes Phosphorylcholine Hemocyanins Choline

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bottomly K

Mathieson B J

Mosier D E

References (21)

21 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.148.5.1216

Published

1978-11-01

Pages

1216-27

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2185045

Subset

External Links

PubMed source DOI: 10.1084/jem.148.5.1216 PMC Full Text View journal details

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Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice.

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