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PMID: 6570083 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Lack of reproducibility of macrodilution MBCs for Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 6 ·1984-12-00 ·Pages 815-8

Pelletier LL

Abstract

MBCs of methicillin, oxacillin, penicillin G, cephalothin, vancomycin, and gentamicin were determined by a standard broth macrodilution technique for 101 clinical isolates of methicillin-susceptible Staphylococcus aureus. Increased killing (more than 99.9%) was observed after 48 versus 24 h of incubation for many strains, and cross tolerance to antimicrobial bactericidal activity (less than 99.9% killing) was frequently observed among antimicrobial agents. However, these in vitro measurements of bactericidal activity against S. aureus were not reproducible.

MeSH Terms
Anti-Bacterial Agents/pharmacology Cephalothin/pharmacology Methicillin/pharmacology Microbial Sensitivity Tests Oxacillin/pharmacology Penicillin Resistance Staphylococcus aureus/drug effects,growth & development Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Vancomycin Methicillin Cephalothin Oxacillin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pelletier L L
References (31)
31 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.26.6.815
Published
1984-12-00
Pages
815-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC180030
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.26.6.815 PMC Full Text View journal details
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