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PMID: 6572280 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human adenovirus type 2 but not adenovirus type 12 is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned rat liver epithelial cells.

Journal of virology ·Vol. 46 ·No. 1 ·1983-04-00 ·Pages 131-6

Paraskeva C, Roberts C, Biggs P, Gallimore PH

Abstract

Using resistance to the base analog 8-azaguanine as a genetic marker, we showed that adenovirus type 2, but not adenovirus type 12, is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned diploid rat liver epithelial cells. Adenovirus type 2 increased the frequency of 8-azaguanine-resistant colonies by up to ninefold over the spontaneous frequency, depending on expression time and virus dose.

MeSH Terms
Adenoviruses, Human/genetics Animals Azaguanine Clone Cells Drug Resistance, Microbial Epithelial Cells Genes, Viral Genetic Markers Hypoxanthine Phosphoribosyltransferase/genetics Liver/cytology Mutation Rats
Chemicals
Genetic Markers Hypoxanthine Phosphoribosyltransferase Azaguanine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Paraskeva C
Roberts C
Biggs P
Gallimore P H
References (23)
23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.46.1.131-136.1983
Published
1983-04-00
Pages
131-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255100
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.46.1.131-136.1983 PMC Full Text View journal details
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