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PMID: 658632 Published · ppublish English Journal Article

Insulin receptors on monocytes of young healthy persons correlated with glucose tolerance and insulin sensitivity.

Diabetologia ·Vol. 14 ·No. 3 ·1978-03-00 ·Pages 159-63

Beck-Nielsen H, Pedersen O

Abstract

We have studied in normal man the interrelationships between insulin binding to monocytes, glucose tolerance and insulin sensitivity. In 25 young healthy persons we found a significant positive correlation between insulin binding and glucose disappearance rate both after glucose (R = 0.68, p less than 0.001) and insulin (R = 0.49, p less than 0.02) given intravenously.

MeSH Terms
Adult Blood Glucose/metabolism Body Weight Female Glucose Tolerance Test Humans Insulin/blood Male Monocytes/metabolism Receptor, Insulin/metabolism
Chemicals
Blood Glucose Insulin Receptor, Insulin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Beck-Nielsen H
Pedersen O
References (19)
19 references, click to expand
  1. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.
    Proc Natl Acad Sci U S A. 1974 Jan;71(1):84-8 PMID: 4359334
  2. The significance and interpretation of mildly abnormal oral glucose tolerance.
    Diabetologia. 1971 Jun;7(3):173-80 PMID: 5560919
  3. Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects.
    J Clin Invest. 1976 Dec;58(6):1435-41 PMID: 993352
  4. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus.
    Br Med J. 1962 Jun 2;1(5291):1507-13 PMID: 14467359
  5. Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.
    J Clin Invest. 1976 Nov;58(5):1123-35 PMID: 993336
  6. Characteristics of the human lymphocyte insulin receptor.
    J Biol Chem. 1973 Mar 25;248(6):2202-7 PMID: 4347860
  7. The monocyte as a model for the study of insulin receptors in man.
    Diabetologia. 1977 Dec;13(6):563-9 PMID: 590649
  8. Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.
    J Clin Invest. 1976 May;57(5):1165-72 PMID: 177453
  9. Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes.
    Biochem Biophys Res Commun. 1971 Apr 16;43(2):400-8 PMID: 5577450
  10. Receptor-binding assay of chemically modified insulins. Comparison with in vitro and in vivo bioassays.
    Diabetologia. 1974 Feb;10(1):1-5 PMID: 4365215
  11. A study of insulin receptors in human mononuclear leucocytes.
    Acta Endocrinol (Copenh). 1976 Nov;83(3):556-64 PMID: 185872
  12. The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.
    J Clin Invest. 1976 Apr;57(4):842-51 PMID: 181402
  13. A SERUM GLUCOSE METHOD WITHOUT PROTEIN PRECIPITATION.
    Am J Med Technol. 1965 Jan-Feb;31:17-21 PMID: 14243687
  14. Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity.
    Proc Natl Acad Sci U S A. 1971 Aug;68(8):1833-7 PMID: 4331561
  15. The relationship between the insulin-binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells.
    J Biol Chem. 1971 Oct 25;246(20):6210-6 PMID: 5127426
  16. "What is inherited--what is added" hypothesis for the pathogenesis of diabetes mellitus.
    Diabetes. 1967 Sep;16(9):615-27 PMID: 6068654
  17. Cytochemical identification of monocytes and granulocytes.
    Am J Clin Pathol. 1971 Mar;55(3):283-90 PMID: 5549896
  18. The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells.
    Diabetologia. 1974 Apr;10(2):105-13 PMID: 4367434
  19. The insulin receptor in normal and obese persons.
    Acta Endocrinol (Copenh). 1976 Nov;83(3):565-75 PMID: 185873
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00429775
Published
1978-03-00
Pages
159-63
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00429775 View journal details
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