Isolation and primary structure of two peptides with cardioacceleratory and hyperglycemic activity from the corpora cardiaca of Periplaneta americana.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 17 ·1984-09-00 ·Pages 5575-9

Scarborough RM, Jamieson GC, Kalish F, Kramer SJ, McEnroe GA, Miller CA, Schooley DA

Abstract

Two cardioacceleratory peptides from the corpora cardiaca of Periplaneta americana have been purified by gel filtration and reversed-phase liquid chromatography, Based on analysis of the intact factors and their chymotryptic fragments, we have assigned the primary structure of these octapeptides as pGlu-Val-Asn-Phe-Ser-Pro-Asn-Trp-NH2, designated periplanetin CC-1, and pGlu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-NH2, designated periplanetin CC-2. They represent new members of a family of invertebrate peptides that includes locust adipokinetic hormone and crustacean red-pigment concentrating hormone. Both peptides show adipokinetic activity in grasshoppers and hyperglycemic activity in cockroaches. One of these peptides (CC-2) has provocative sequence homology with the NH2-terminal portion of glucagon.

MeSH Terms

Amino Acid Sequence Animals Chromatography, High Pressure Liquid Cockroaches Grasshoppers Heart Rate/drug effects Hemolymph Hyperglycemia/chemically induced Molecular Weight Peptides/isolation & purification,pharmacology,toxicity

Chemicals

Peptides

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Scarborough R M

Jamieson G C

Kalish F

Kramer S J

McEnroe G A

Miller C A

Schooley D A

References (12)

12 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.81.17.5575

Published

1984-09-00

Pages

5575-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC391749

Subset

External Links

PubMed source DOI: 10.1073/pnas.81.17.5575 PMC Full Text View journal details

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Isolation and primary structure of two peptides with cardioacceleratory and hyperglycemic activity from the corpora cardiaca of Periplaneta americana.

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