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PMID: 6592118 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

A 'new' DR4 associated D specificity 'JA' in type 1 (insulin-dependent) diabetes: A9, Bw16, DJA, DR4 haplotype.

Diabetologia ·Vol. 27 Suppl ·1984-07-00 ·Pages 126-8

Mustonen A, Ilonen J, Surcel HM, Akerblom HK

Abstract

The HLA antigen combination A9, Bw16 has been found to be associated with Type 1 (insulin-dependent) diabetes characterized by some special features in Northern Finland. This antigen combination has now been associated with a 'new' DR4-associated D antigen, provisionally called 'JA' or 'SN'. This 'new' D specificity was also associated with HLA-B18. Although the combination, Dw3/DJA, was common in Type 1 diabetic patients, the frequency of the combination Dw4/DJA was decreased compared with the expected value. This supports the hypothesis of two different risk factors associated with DR3 and DR4.

MeSH Terms
Diabetes Mellitus, Type 1/genetics,immunology Finland Gene Frequency HLA Antigens/genetics HLA-DR Antigens Histocompatibility Antigens Class II/genetics Humans
Chemicals
HLA Antigens HLA-DR Antigens Histocompatibility Antigens Class II
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mustonen A
Ilonen J
Surcel H M
Akerblom H K
References (10)
10 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00275668
Published
1984-07-00
Pages
126-8
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00275668 View journal details
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