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PMID: 6608107 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 4 ·1984-02-00 ·Pages 1221-4

Rock KL, Benacerraf B

Abstract

Murine thymocytes induce the monokine interleukin 1 upon in vitro coculture with a radioresistant Ia-bearing accessory cell [murine Ia molecule is a class II major histocompatibility complex (MHC) antigen]. The generation of interleukin 1 is critically dependent on the function of I-region gene products on accessory cells. The induced interleukin 1 appears to allow the activation and proliferation of self-MHC-specific thymocytes. Thus, in the absence of added exogenous factors, there is an Ia-dependent thymocyte proliferation. This selective activation of thymocytes is observed with both mature and immature thymic T cells. This in vitro response results in the selective amplification of developing T cells with self-MHC specificity and could be of importance to the in vivo commitment of T cells to MHC determinants that occurs in the thymus.

MeSH Terms
Animals Antibodies, Monoclonal Cells, Cultured DNA Replication Female Interleukin-1/genetics Interleukin-2/genetics Kinetics Lymphocyte Activation Major Histocompatibility Complex Mice Mice, Inbred Strains Spleen/immunology T-Lymphocytes/immunology Thymus Gland/immunology
Chemicals
Antibodies, Monoclonal Interleukin-1 Interleukin-2
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rock K L
Benacerraf B
References (28)
28 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.4.1221
Published
1984-02-00
Pages
1221-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC344798
Subset
IM
Grants
NIAID NIH HHS · 1R01-AI-CA-20248-01 · United States
NCI NIH HHS · 2T32-CA-09130-06 · United States
NIAID NIH HHS · AI-14732 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.4.1221 PMC Full Text View journal details
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