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PMID: 66198 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

In vitro studies on H-2 linked unresponsiveness. 1. Normal helper cells to (T,G)-A-L and GAT in low and non-responder mice.

Immunology ·Vol. 32 ·No. 3 ·1977-03-00 ·Pages 291-9

Howie S, Feldmann M, Mozes E, Maurer PH

Abstract

Lymphoid cells from unprimed high responder (C57BL/10) and low responder mice (B10.Br, B10.A, CBA) to (T,G)-A-L and high responder (B10, B10.A) and non-responder (B10.G, DBA/I) mice to GAT can be induced to form antigen specific T-helper cells in vitro under identical culture conditions. The helper cells induced from high and low or non-responder mice appear to be identical in efficiency, antigen concentration requirement for induction and induction kinetics.

MeSH Terms
Animals Antibody-Producing Cells Antigens B-Lymphocytes/immunology Cells, Cultured Dose-Response Relationship, Immunologic Epitopes Histocompatibility Mice Mice, Inbred Strains Peptides/immunology T-Lymphocytes/immunology Time Factors
Chemicals
Antigens Epitopes Peptides
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Howie S
Feldmann M
Mozes E
Maurer P H
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22 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1977-03-00
Pages
291-9
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1445284
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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