Anti-immunoglobulin antibodies. I. Expression of cross-reactive idiotypes and Ir gene control of the response to IgG2a of the b allotype.
The anti-allotype antibody response to the b allotypic form of IgG2a is regulated by major histocompatibility complex (MHC)-encoded immune response (Ir) genes. Mice of d, b, p, q, r, and s haplotypes make a strong anti-allotype response on immunization with the CBPC101 myeloma protein (IgG2ab), whereas mice of the k, m, a, a1, u, and z haplotypes made no, or a very poor, response. All responder strains produce anti-IgG2ab antibodies which share common idiotypes (Id) without relation to the allelic forms of the Ig heavy-chain-constant region genes that the responding mice possess. Isoelectric focusing analysis of the anti-allotype antibodies produced in various strains of mice showed that they are of limited heterogeneity and quite similar from strain to strain. Five out of six hybridoma products with specificity for CBPC101 allotype expressed cross-reactive idiotypes (IdX). Two of hybridoma products expressing IdX identify CH3-domain determinants, and one has been assigned a CH2-domain specificity.
21 references, click to expand
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Induction of T and B cell immunity by anti-idiotypic antibody.Eur J Immunol. 1975 Oct;5(10):661-6 PMID: 11993330
-
Association of H-2 types with genetic control of immune responsiveness to IgA allotypes in the mouse.Proc Natl Acad Sci U S A. 1971 Oct;68(10):2510-3 PMID: 5289884
-
Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function.Proc Natl Acad Sci U S A. 1971 Oct;68(10):2616-20 PMID: 4109410
-
Active suppression of immunoglobulin allotype synthesis. I. Chronic suppression after perinatal exposure to maternal antibody to paternal allotype in (SJL x BALB-c)F 1 mice.J Exp Med. 1972 May 1;135(5):1151-62 PMID: 4623316
-
Specific suppression of the antibody response by antibodies to receptors.Proc Natl Acad Sci U S A. 1972 Sep;69(9):2701-5 PMID: 4403565
-
Association of H-2 types with genetic control of immune reponsiveness to IgG (gamma2a) allotypes in the mouse.J Exp Med. 1972 Nov 1;136(5):1222-30 PMID: 4117189
-
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.J Exp Med. 1973 Feb 1;137(2):331-42 PMID: 4119588
-
[Idiotype of antibodies, in the serum of rabbits immunized against human fibrinogen, directed against 2 different fragments of this antigen].C R Acad Sci Hebd Seances Acad Sci D. 1973 Jan 8;276(2):243-5 PMID: 4121066
-
Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities.J Exp Med. 1974 Jan 1;139(1):128-36 PMID: 4543460
-
T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.J Exp Med. 1976 Aug 1;144(2):330-44 PMID: 1085324
-
Presence on idiotype-specific suppressor T cells of receptors that interact with molecules bearing the idiotype.J Exp Med. 1977 Jun 1;145(6):1559-66 PMID: 325170
-
Idiotypes on galactan binding myeloma proteins and anti-galactan antibodies in mice.J Immunol. 1977 Dec;119(6):1888-93 PMID: 72109
-
Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice.J Exp Med. 1977 Nov 1;146(5):1436-49 PMID: 336835
-
Differential expression of an equivalent clonotype among BALB/c and C57BL/6 mice.J Exp Med. 1978 Jan 1;147(1):1-12 PMID: 75230
-
Immunological studies of T-cell receptors. II. Limited polymorphism of idiotypic determinants on T-cell receptors specific for major histocompatibility complex alloantigens.J Exp Med. 1979 Jan 1;149(1):234-43 PMID: 33224
-
Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype.J Exp Med. 1979 Mar 1;149(3):592-600 PMID: 85681
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Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes.J Exp Med. 1979 Apr 1;149(4):815-23 PMID: 85684
-
Immune response to levan. II. T independence of suppression of cross-reactive idiotypes by anti-idiotype antibodies.J Immunol. 1979 Apr;122(4):1614-9 PMID: 376722
-
Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny.J Immunol. 1979 Oct;123(4):1484-90 PMID: 383836
-
Tritium (3H) radiolabeling of protein A and antibody to high specific activity: application to cell surface antigen radioimmunoassays.J Immunol Methods. 1979;28(3-4):255-66 PMID: 479606
-
Idiotypic analysis of anti-GAT antibodies. I. Presence of common idiotypic specificities in both responder and nonresponder mice.J Immunol. 1978 Sep;121(3):1034-9 PMID: 690432
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