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PMID: 6776038 Published · ppublish English Journal Article

J segment in human delta chains.

Immunology ·Vol. 40 ·No. 4 ·1980-08-00 ·Pages 657-64

Milstein CP, Deverson EV

Abstract

We report the complete sequence of a cyanogen bromide fragment of a human delta chain (ErI). Its interest lies in the fact that it contains the peptide joining the V delta to the C delta 1 region. The presented sequence is compared with the homologous region of other human heavy chain classes and subclasses. The possibility that human delta chains and other human heavy chains have in their chromosomal DNA a short J sequence, is discussed.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Chemical Phenomena Chemistry Chromatography, Gel Cyanogen Bromide Humans Immunoglobulin Heavy Chains Immunoglobulin delta-Chains Pepsin A Peptide Fragments/analysis Trypsin
Chemicals
Amino Acids Immunoglobulin Heavy Chains Immunoglobulin delta-Chains Peptide Fragments Trypsin Pepsin A Cyanogen Bromide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Milstein C P
Deverson E V
References (28)
28 references, click to expand
  1. Electrophoretic mobilities of peptides on paper and their use in the determination of amide groups.
    Nature. 1966 Aug 6;211(5049):591-3 PMID: 5968723
  2. Separation of dansyl-amino acids by polyamide layer chromatography.
    Biochim Biophys Acta. 1967 Feb 21;133(2):369-70 PMID: 6029938
  3. Comparative studies of two types of bovine immunoglobulin G heavy chains.
    Biochem J. 1968 Apr;107(4):559-64 PMID: 4173472
  4. A simple procedure for the fractionation of the tryptic peptides of the C-terminal half of immunoglobulin lambda-chains.
    Biochem J. 1968 Dec;110(4):652-4 PMID: 4178701
  5. Sequence studies of the Fd section of the heavy chain of rabbit immunoglobulin G.
    Biochem J. 1970 Jan;116(2):249-59 PMID: 5461106
  6. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain.
    Biochem J. 1970 Mar;117(1):33-47 PMID: 4192699
  7. The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains.
    Biochem J. 1970 May;117(4):641-60 PMID: 5449120
  8. Interchain bridges of human IgD.
    Nature. 1970 Dec 5;228(5275):934-5 PMID: 5482104
  9. The genetic basis of antibody specificity.
    Annu Rev Microbiol. 1970;24:335-58 PMID: 4927134
  10. Sequence of amino acids of the NH 2 -terminal region of a mouse-clonal immunoglobulin heavy chain.
    Eur J Biochem. 1972 Jan 21;24(3):446-55 PMID: 5062012
  11. The genetic control of immunoglobulin synthesis.
    Annu Rev Genet. 1972;6:1-46 PMID: 4124595
  12. Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin.
    Science. 1973 Oct 19;182(4109):287-91 PMID: 4742735
  13. Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein.
    Biochemistry. 1974 Sep 10;13(19):4033-8 PMID: 4213527
  14. [The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu-type), subgroup H III. Architecture of the complete IgM-molecule (author's transl)].
    Hoppe Seylers Z Physiol Chem. 1973 Oct-Nov;354(10-11):1505-9 PMID: 4803843
  15. NH2-terminal amino acid sequence of the Fc fragment of IgD resembles IgE and IgG sequences.
    Nature. 1975 Apr 24;254(5502):723-5 PMID: 1124134
  16. [The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)].
    Hoppe Seylers Z Physiol Chem. 1975 Aug;356(8):1337-42 PMID: 809331
  17. N-terminal amino acid sequence of a human delta-chain myeloma protein.
    Eur J Immunol. 1976 Mar;6(3):222-4 PMID: 825370
  18. The structure and biology of human IgD.
    Immunol Rev. 1977;37:3-24 PMID: 338468
  19. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.
    Nature. 1979 Feb 22;277(5698):627-33 PMID: 106304
  20. Structure of the A2m(1) allotype of human IgA--a recombinant molecule.
    Proc Natl Acad Sci U S A. 1979 Mar;76(3):1104-8 PMID: 286295
  21. Tryptic degradation of the CH1 and VL regions of IgD and IgE.
    J Immunol. 1979 Apr;122(4):1190-5 PMID: 448085
  22. Sequences at the somatic recombination sites of immunoglobulin light-chain genes.
    Nature. 1979 Jul 26;280(5720):288-94 PMID: 111144
  23. A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation.
    Nature. 1979 Aug 2;280(5721):370-5 PMID: 111146
  24. Structural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2890-4 PMID: 111245
  25. Amino acid sequence of a mouse immunoglobulin mu chain.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2932-6 PMID: 111247
  26. The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein.
    Can J Biochem. 1979 Jun;57(6):758-67 PMID: 113060
  27. Correlation between fragmented immunoglobulin genes and heavy chain deletion mutants.
    Nature. 1979 Oct 18;281(5732):600-2 PMID: 114864
  28. Amino acid sequence of a mouse myeloma immunoglobin heavy chain (MOPC 47 A) with a 100-residue deletion.
    J Biol Chem. 1979 Nov 25;254(22):11418-30 PMID: 115869
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1980-08-00
Pages
657-64
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1458091
Subset
IM
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