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PMID: 6795075 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Haemostatic changes in diabetic coma.

Diabetologia ·Vol. 21 ·No. 3 ·1981-09-00 ·Pages 172-7

Paton RC

Abstract

Diabetic coma is frequently associated with thromboembolic complications. A prospective study was undertaken of the haemostatic changes occurring in 15 patients (12 with ketoacidosis, three with the hyperosmolar syndrome) during diabetic coma. When compared with the results after stabilization of the diabetes, ketoacidosis was associated with significantly higher levels of factor VIII coagulant activity, factor VIII-related antigen and fibrin degradation products, a shorter partial thromboplastin time and reduced concentrations of antithrombin III. These results suggest that in uncomplicated ketoacidosis, haematological changes occur which may reflect vascular endothelial damage and intravascular fibrin deposition. Out of three deaths, two patients (both with the hyperosmolar syndrome) had evidence of disseminated intravascular coagulation. To reduce further the mortality and morbidity from diabetic coma, controlled clinical trials of anticoagulant and antiplatelet drugs may be indicated.

MeSH Terms

Adolescent Adult Aged Blood Coagulation Factors/analysis Diabetic Coma/physiopathology Diabetic Ketoacidosis/physiopathology Female Hematocrit Hemostasis Humans Hyperglycemic Hyperosmolar Nonketotic Coma/physiopathology Male Middle Aged

Chemicals

Blood Coagulation Factors

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Paton R C

References (27)

27 references, click to expand

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Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

0012-186X

DOI

10.1007/BF00252650

Published

1981-09-00

Pages

172-7

Language

English

Region

Germany

NLM ID

0006777

Subset

External Links

PubMed source DOI: 10.1007/BF00252650 View journal details

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Haemostatic changes in diabetic coma.

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