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PMID: 6822426 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Possible chemotaxis of human monocytes by N-acetylmuramyl-L-alanyl-D-isoglutamine.

Infection and immunity ·Vol. 39 ·No. 1 ·1983-01-00 ·Pages 449-51

Ogawa T, Kotani S, Kusumoto S, Shiba T

Abstract

N-Acetylmuramyl-l-alanyl-d-isoglutamine (MDP) induced the chemotaxis of human blood monocytes without mediation of serum complement. Specificity (dependency on chemical structure) of the chemotactic activity of MDP was evidenced by a negligible activity of analogs lacking most of the immunomodulating activities of MDP.

MeSH Terms

Acetylmuramyl-Alanyl-Isoglutamine/pharmacology Chemotaxis, Leukocyte/drug effects Humans Monocytes/drug effects,immunology

Chemicals

Acetylmuramyl-Alanyl-Isoglutamine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ogawa T

Kotani S

Kusumoto S

Shiba T

References (9)

9 references, click to expand

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Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors.
J Immunol. 1972 Mar;108(3):857-60 PMID: 5011759
Inhibition of macrophage migration by synthetic muramyl dipeptide.
Biochem Biophys Res Commun. 1978 Feb 28;80(4):923-8 PMID: 637877
Stimulation of migration of human monocytes by bacterial cell walls and muramyl peptides.
Infect Immun. 1982 Dec;38(3):817-24 PMID: 7152675
A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration.
J Immunol Methods. 1980;33(3):239-47 PMID: 6989919
Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.
J Exp Med. 1973 Feb 1;137(2):387-410 PMID: 4568301
Rapid quantitation of neutrophil chemotaxis: use of a polyvinylpyrrolidone-free polycarbonate membrane in a multiwell assembly.
J Immunol Methods. 1980;37(1):39-45 PMID: 7000913
Inhibition of macrophage migration by muramyl peptides.
Infect Immun. 1979 May;24(2):308-12 PMID: 457276
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.
J Exp Med. 1962 Mar 1;115:453-66 PMID: 13872176

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.39.1.449-451.1983

Published

1983-01-00

Pages

449-51

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC347960

Subset

External Links

PubMed source DOI: 10.1128/iai.39.1.449-451.1983 PMC Full Text View journal details

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Possible chemotaxis of human monocytes by N-acetylmuramyl-L-alanyl-D-isoglutamine.

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