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PMID: 6831625 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Time dependency of adriamycin and adriamycinol kinetics.

Cancer chemotherapy and pharmacology ·Vol. 10 ·No. 2 ·1983-00-00 ·Pages 120-4

Gil P, Favre R, Durand A, Iliadis A, Cano JP, Carcassonne Y

Abstract

Adriamycin was administered by IV injection to seven patients with various solid tumors at a dose of 30 mg/m2 during successive courses. Extraction was carried out by the SEP-PAK method for plasma and by solvents for urine. Plasma and urinary levels of adriamycin and adriamycinol were determined by high-performance liquid chromatography over 72-h period after injection. Pharmacokinetic parameters for adriamycin and adriamycinol were calculated for each course of treatment. The results show significant inter- and intra-individual variations in the kinetics and elimination of both compounds. The analysis of pharmacokinetic data reveals a wide variability in the fluctuations observed during the successive courses in different patients. This study confirms the time-dependency of ADR kinetics.

MeSH Terms
Adult Aged Alanine Transaminase/blood Alkaline Phosphatase/blood Aspartate Aminotransferases/blood Chromatography, High Pressure Liquid Doxorubicin/analogs & derivatives,metabolism,therapeutic use,urine Female Half-Life Humans Kinetics Male Middle Aged Neoplasms/drug therapy Time Factors
Chemicals
Doxorubicin Aspartate Aminotransferases Alanine Transaminase Alkaline Phosphatase adriamycinol
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Gil P
Favre R
Durand A
Iliadis A
Cano J P
Carcassonne Y
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21 references, click to expand
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Article Info
Journal
Cancer chemotherapy and pharmacology
Abbr.
Cancer Chemother Pharmacol
ISSN
0344-5704
DOI
10.1007/BF00446223
Published
1983-00-00
Pages
120-4
Language
English
Region
Germany
NLM ID
7806519
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00446223 View journal details
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