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PMID: 6857581 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Localisation of a low-molecular-weight bronchial protease inhibitor in the peripheral human lung.

Thorax ·Vol. 38 ·No. 3 ·1983-03-00 ·Pages 180-3

Mooren HW, Kramps JA, Franken C, Meijer CJ, Dijkman JA

Abstract

The localisation of a low-molecular-weight bronchial protease inhibitor (LMI) in human peripheral lung tissue was studied by an immunohistochemical method. This inhibitor was found exclusively in a part of the non-ciliated cell population of the bronchiolar epithelium. An inverse relationship was observed between the number of LMI-positive non-ciliated cells per millimetre of basement membrane and the bronchiolar diameter. These findings may have a bearing on the protease-antiprotease theory of the development of pulmonary emphysema, LMI possibly playing a part in the protection of peripheral lung tissue against proteolytic destruction by enzymes liberated from granulocytes or migrating alveolar macrophages.

MeSH Terms
Bronchi/analysis,cytology Epithelial Cells Epithelium/analysis Histocytochemistry Humans Molecular Weight Protease Inhibitors/analysis
Chemicals
Protease Inhibitors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Mooren H W
Kramps J A
Franken C
Meijer C J
Dijkman J A
References (19)
19 references, click to expand
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Article Info
Journal
Thorax
Abbr.
Thorax
ISSN
0040-6376
DOI
10.1136/thx.38.3.180
Published
1983-03-00
Pages
180-3
Language
English
Region
England
NLM ID
0417353
PMCID
PMC459515
Subset
IM
External Links
PubMed source DOI: 10.1136/thx.38.3.180 PMC Full Text View journal details
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