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PMID: 6859039 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Heritable fragile sites on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23.

American journal of human genetics ·Vol. 35 ·No. 3 ·1983-05-00 ·Pages 432-7

Sutherland GR, Jacky PB, Baker E, Manuel A

Abstract

Four new folate-sensitive fragile sites are documented at 6p23, 9p21, 9q32, and 11q23. These have all been shown to be heritable except for the one at 9p21, which has been seen only in a single individual. As with the other autosomal fragile sites, these appear to be innocuous in heterozygotes.

MeSH Terms
Child Child, Preschool Chromosome Fragile Sites Chromosome Fragility Chromosomes, Human/drug effects Chromosomes, Human, 6-12 and X Culture Media Dose-Response Relationship, Drug Female Folic Acid/pharmacology Humans Infant, Newborn Karyotyping Male Pedigree Thymidine/pharmacology
Chemicals
Culture Media Folic Acid Thymidine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sutherland G R
Jacky P B
Baker E
Manuel A
References (9)
9 references, click to expand
  1. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.
    Am J Hum Genet. 1979 Mar;31(2):125-35 PMID: 36752
  2. Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics.
    Am J Hum Genet. 1979 Mar;31(2):136-48 PMID: 453198
  3. FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.
    Am J Hum Genet. 1981 Mar;33(2):234-42 PMID: 6452060
  4. Heritable fragile sites on human chromosomes. VI. Characterization of the fragile site at 12q13.
    Hum Genet. 1981;57(2):217-9 PMID: 7194847
  5. Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal.
    Am J Hum Genet. 1981 Nov;33(6):946-9 PMID: 7325157
  6. 5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation.
    J Med Genet. 1981 Oct;18(5):374-6 PMID: 6460104
  7. Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites.
    Am J Hum Genet. 1982 May;34(3):452-8 PMID: 7081222
  8. [Genetic aspects of autosomal fragile sites. Apropos of 40 Cases].
    J Genet Hum. 1982 Oct;30(3):183-97 PMID: 7153767
  9. The fragile X chromosome.
    Int Rev Cytol. 1983;81:107-43 PMID: 6347931
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1983-05-00
Pages
432-7
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685660
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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