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PMID: 7325157 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal.

American journal of human genetics ·Vol. 33 ·No. 6 ·1981-11-00 ·Pages 946-9

Sutherland GR

Abstract

A brother and sister have been detected who are homozygous for the bromodeoxyuridine (BrdU)-requiring fragile site at 10q25. The children are phenotypically normal, indicating that homozygosity for this fragile site is harmless, at least during childhood.

MeSH Terms
Bromodeoxyuridine/genetics Child Chromosome Fragile Sites Chromosome Fragility Chromosomes, Human, 6-12 and X Female Homozygote Humans Infant Male Pedigree Phenotype
Chemicals
Bromodeoxyuridine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sutherland G R
References (6)
6 references, click to expand
  1. A homozygous chromosomal variant.
    Lancet. 1969 Mar 8;1(7593):531 PMID: 4179603
  2. Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics.
    Am J Hum Genet. 1979 Mar;31(2):136-48 PMID: 453198
  3. Demonstration of a heritable fragile site in human chromosome 16 with distamycin A.
    Cytogenet Cell Genet. 1980;28(1-2):87-94 PMID: 7449440
  4. Heritable fragile sites and lymphocyte culture medium containing BrdU.
    Am J Hum Genet. 1980 Jul;32(4):628-9 PMID: 7395874
  5. Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27).
    N Engl J Med. 1980 Sep 18;303(12):662-4 PMID: 6931286
  6. Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression.
    Am J Hum Genet. 1980 Jul;32(4):542-8 PMID: 7395866
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1981-11-00
Pages
946-9
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685152
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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