Home LiteratureArticle Details
PMID: 6877238 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Tandem arrangement of tubulin genes in the protozoan parasite Leishmania enriettii.

Molecular and cellular biology ·Vol. 3 ·No. 6 ·1983-06-00 ·Pages 1070-6

Landfear SM, McMahon-Pratt D, Wirth DF

Abstract

The arrangement of developmentally regulated alpha- and beta-tubulin genes has been studied in the parasitic protozoan Leishmania enriettii by using Southern blot hybridization analysis. The alpha-tubulin genes occur in a tandem repeat whose monomeric unit may be represented by a 2-kilobase PstI fragment. Similarly, the beta-tubulin genes probably occur in a separate tandem repeat consisting of approximately 4-kilobase units unlinked to the alpha-tubulin repeats.

MeSH Terms
Animals Genes Genetic Linkage Leishmania/genetics Repetitive Sequences, Nucleic Acid Tubulin/genetics
Chemicals
Tubulin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Landfear S M
McMahon-Pratt D
Wirth D F
References (34)
34 references, click to expand
  1. A membrane-filter technique for the detection of complementary DNA.
    Biochem Biophys Res Commun. 1966 Jun 13;23(5):641-6 PMID: 5963888
  2. Studies on kinetoplast DNA. 3. Kinetic complexity of kinetoplast and nuclear DNA from Leishmania tarentolae.
    Biochim Biophys Acta. 1973 Sep 7;319(3):267-76 PMID: 4747081
  3. Isolation and partial characterization of alpha and beta-tubulin from outer doublets of sea-urchin sperm and microtubules of chick-embryo brain.
    Proc Natl Acad Sci U S A. 1973 Dec;70(12):3594-8 PMID: 4519648
  4. Programmed synthesis of tubulin for the flagella that develop during cell differentiation in Naegleria gruberi.
    Proc Natl Acad Sci U S A. 1974 Jul;71(7):2877-81 PMID: 4604968
  5. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  6. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
    J Mol Biol. 1977 Jun 15;113(1):237-51 PMID: 881736
  7. Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5350-4 PMID: 414220
  8. Sequence arrangement of the 16S and 26S rRNA genes in the pathogenic haemoflagellate Leishmania donovani.
    Nucleic Acids Res. 1978 Feb;5(2):491-504 PMID: 634795
  9. Spliced early mRNAs of simian virus 40.
    Proc Natl Acad Sci U S A. 1978 Mar;75(3):1274-8 PMID: 206891
  10. Mechanisms of regulating tubulin synthesis in cultured mammalian cells.
    Cell. 1979 Jun;17(2):319-25 PMID: 455467
  11. Programmed appearance of translatable flagellar tubulin mRNA during cell differentiation in Naegleria.
    Cell. 1979 Aug;17(4):867-78 PMID: 487433
  12. Mutation in a structural gene for a beta-tubulin specific to testis in Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1979 Aug;76(8):3991-5 PMID: 115008
  13. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.
    Cell. 1980 May;20(1):95-105 PMID: 6893015
  14. Increased levels of mRNAs for tubulin and other flagellar proteins after amputation or shortening of Chlamydomonas flagella.
    Cell. 1980 Jun;20(2):469-77 PMID: 6156007
  15. Mutation in a testis-specific beta-tubulin in Drosophila: analysis of its effects on meiosis and map location of the gene.
    Cell. 1980 Sep;21(2):445-51 PMID: 6773669
  16. Structural analysis of variant and invariant genes in trypanosomes.
    Am J Trop Med Hyg. 1980 Sep;29(5 Suppl):1043-9 PMID: 7435803
  17. A dispersed multigene family encoding tubulin in Drosophila melanogaster.
    Cell. 1980 Dec;22(3):845-54 PMID: 6780200
  18. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs.
    Nature. 1981 Feb 19;289(5799):650-5 PMID: 7464932
  19. Multiple alpha- and beta-tubulin genes in Chlamydomonas and regulation of tubulin mRNA levels after deflagellation.
    Cell. 1981 Apr;24(1):81-8 PMID: 6263492
  20. alpha-Tubulin genes of Drosophila.
    Cell. 1981 Apr;24(1):97-106 PMID: 6263493
  21. Complete amino acid sequence of alpha-tubulin from porcine brain.
    Proc Natl Acad Sci U S A. 1981 May;78(5):2757-61 PMID: 7019911
  22. Structural variation among human beta-tubulin genes.
    Proc Natl Acad Sci U S A. 1981 Aug;78(8):4877-81 PMID: 6946435
  23. Structure of two human alpha-tubulin genes.
    Proc Natl Acad Sci U S A. 1982 Jan;79(1):96-100 PMID: 6275393
  24. Nucleotide sequence and evolution of a mammalian alpha-tubulin messenger RNA.
    J Mol Biol. 1981 Sep 5;151(1):101-20 PMID: 7328649
  25. Tubulin biosynthesis in the developmental cycle of a parasitic protozoan, Leishmania mexicana: changes during differentiation of motile and nonmotile stages.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7624-8 PMID: 6950404
  26. Regulation of tubulin gene expression during embryogenesis in Drosophila melanogaster.
    Cell. 1982 Jan;28(1):33-40 PMID: 6802501
  27. Evidence that a human beta-tubulin pseudogene is derived from its corresponding mRNA.
    Nature. 1982 May 6;297(5861):83-4 PMID: 7070533
  28. Isolation of a multigene family containing human alpha-tubulin sequences.
    J Mol Biol. 1982 Mar 15;155(4):533-8 PMID: 6283097
  29. Post-translational modification of tubulin dependent on organelle assembly.
    Nature. 1982 Jun 10;297(5866):516-8 PMID: 7088133
  30. Developmental regulation of Drosophila alpha-tubulin genes.
    Cell. 1982 May;29(1):91-8 PMID: 6179633
  31. Post-transcriptional control of tubulin biosynthesis during leishmanial differentiation.
    Nature. 1982 Oct 14;299(5884):650-2 PMID: 7121597
  32. The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element.
    Nature. 1982 Nov 25;300(5890):330-5 PMID: 6927856
  33. Biochemical and structural analyses of microtubules in the pellicular membrane of Leishmania tropica.
    J Protozool. 1982 Nov;29(4):560-5 PMID: 7175771
  34. Tubulin genes are tandemly linked and clustered in the genome of trypanosoma brucei.
    Cell. 1983 Jan;32(1):35-43 PMID: 6825172
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.3.6.1070-1076.1983
Published
1983-06-00
Pages
1070-6
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368636
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.3.6.1070-1076.1983 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2