Evolution of an idiotypic determinant: anti-Val.
An antibody population which reacts only with human sickle cell hemoglobin (HbS) and not with normal human hemoglobin, has been isolated from goat, sheep, and guinea pig antisera. These antibody populations termed anti-Val (Val), isolated from an individual goat (no. 6) and sheep (no. 26) have been used to elicit anti-idiotypic responses in rabbits. These anti-idiotypic sera were used to study the idiotypic cross-reactions between the goat and sheep anti-Val. Strong cross-reactions were present using either Ra anti-goat anti-Val or Ra anti-sheep anti-Val. Guinea pig anti-Val did not cross-react with these anti-idiotypic sera. Binding of HbS to the anti-Val of the goat and sheep could be blocked by the anti-idiotypic sera, but the binding of HbS to the guinea pig anti-Val could not. These data demonstrate idiotypic cross-reactivity between two closely related species.
17 references, click to expand
-
Preparation of iodine-131 labelled human growth hormone of high specific activity.Nature. 1962 May 5;194:495-6 PMID: 14450081
-
Quantitative investigations of idiotypic antibodies. IV. Inhibition by specific haptens of the reaction of anti-hapten antibody with its anti-idiotypic antibody.J Exp Med. 1970 Nov;132(5):951-62 PMID: 4097134
-
Common individual antigenic determinants in five of eight BALB-c IgA myeloma proteins that bind phosphoryl choline.J Exp Med. 1970 Oct 1;132(4):737-51 PMID: 4101363
-
The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates.J Exp Med. 1971 Aug 1;134(2):532-52 PMID: 4104426
-
Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains.J Exp Med. 1972 Mar 1;135(3):579-95 PMID: 4110016
-
Studies on antibodies directed toward single antigenic sites on globular proteins.Biochemistry. 1972 Aug 29;11(18):3326-32 PMID: 4115656
-
Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine.Eur J Immunol. 1972 Aug;2(4):319-26 PMID: 4117282
-
Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody.Proc Natl Acad Sci U S A. 1973 Jan;70(1):235-9 PMID: 4119224
-
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.J Exp Med. 1973 Feb 1;137(2):331-42 PMID: 4119588
-
Antigenic specificities related to the cold agglutinin activity of gamma M globulins.Science. 1968 Jul 26;161(3839):379-81 PMID: 4173573
-
Characterization of the antibody to the C-carbohydrate produced by a transplantable mouse plasmacytoma.Immunochemistry. 1969 Jan;6(1):111-23 PMID: 4180087
-
The occurrence of shared idiotypic specificity among the goat antibodies that distinguish human hemoglobin S from A.J Immunol. 1974 Jul;113(1):359-66 PMID: 4208922
-
Isolation from individual A/J mice of anti-rho-azophenylarsonate antibodies bearing a cross-reactive idiotype.J Exp Med. 1975 Jan 1;141(1):112-26 PMID: 46907
-
Detection of idiotypic cross-reactions among streptococcal antisera from related rabbits.J Exp Med. 1973 Sep 1;138(3):522-37 PMID: 4727913
-
Clonal nature of the immune response to phosphorylcholine (PC). V. Cross-idiotypic specificity among heavy chains of murine anti-PC antibodies and PC-binding myeloma proteins.J Exp Med. 1975 May 1;141(5):1073-83 PMID: 47894
-
Mouse strain-specific idiotypy and interstrain idiotypic cross-reactions.J Immunol. 1974 Aug;113(2):522-30 PMID: 4858626
-
Properties of goat anti-human hemoglobin antibodies fractionated on subunit affinity columns.Immunochemistry. 1976 Jun;13(6):491-8 PMID: 985800
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