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PMID: 6941695 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.

American journal of human genetics ·Vol. 33 ·No. 3 ·1981-05-00 ·Pages 381-95

Hodge SE

Abstract

A two-locus disease model is presented in which a marker locus interacts epistatically with another unlinked trait to cause the disease. Such a model can lead to disease-marker associations and distortions in the sharing of marker types among affected family members. These effects are quantified. In the case of HLA-disease associations, this model is presented as an alternative to the "hitchhiking" theory of tight linkage leading to linkage disequilibrium.

MeSH Terms
Alleles Chromosome Mapping Epistasis, Genetic Genetic Diseases, Inborn/genetics Genetic Linkage Genetic Markers HLA Antigens/genetics Humans Models, Genetic Risk
Chemicals
Genetic Markers HLA Antigens
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hodge S E
References (36)
36 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1981-05-00
Pages
381-95
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685026
Subset
IM
Grants
NICHD NIH HHS · HD-04612 · United States
NICHD NIH HHS · HD-05615 · United States
NIMH NIH HHS · MH-33617 · United States
External Links
PubMed source PMC Full Text View journal details
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