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PMID: 6941696 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Some epistatic two-locus models of disease. II. The confounding of linkage and association.

American journal of human genetics ·Vol. 33 ·No. 3 ·1981-05-00 ·Pages 396-406

Hodge SE, Spence MA

Abstract

This paper continues to examine the model discussed in the preceding paper. Specifically, it will be shown how a linkage analysis performed in the presence of a disease-marker association can give rise to erroneous and misleading results.

MeSH Terms
Alleles Chromosome Mapping Epistasis, Genetic Genetic Diseases, Inborn/genetics Genetic Linkage Genetic Markers HLA Antigens/genetics Humans Lod Score Models, Genetic Risk
Chemicals
Genetic Markers HLA Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hodge S E
Spence M A
References (12)
12 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1981-05-00
Pages
396-406
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685039
Subset
IM
Grants
NICHD NIH HHS · HD-04612 · United States
NICHD NIH HHS · HD-05615 · United States
NIMH NIH HHS · MH-33617 · United States
External Links
PubMed source PMC Full Text View journal details
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