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PMID: 6947212 Published · ppublish English Journal Article

5'-O-Monophosphoryladenylyl(2' goes to 5')adenylyl(2' goes to 5')adenosine is an antagonist of the action of 5'-O-triphosphoryladenylyl-(2' goes to 5')adenylyl(2' goes to 5')adenosine and double-stranded RNA.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 10 ·1981-10-00 ·Pages 5993-7

Torrence PF, Imai J, Johnston MI

Abstract

5'-O-Monophosphoryladenylyl(2' goes to 5')adenylyl-(2' goes to 5')adenosine [(2' goes to 5')(pA)3] antagonizes the protein synthesis inhibitory effects of 5'-O-triphosphoryladenylyl-(2' goes to 5')adenylyl(2' goes to 5')adenosine by preventing activation of the (2' goes to 5')oligo(a)-activated ribonuclease which degrades mRNA. The oligoribonucleotide (2' goes to 5')(pA)3 also antagonizes the translational inhibitory capacity of poly(I).poly(C) in extracts of interferon-treated L cells, suggesting that (2' goes to 5')oligo(A) is the primary mediator of the protein synthesis inhibitory effects of poly(I).poly(C) in this cell-free system.

MeSH Terms
Adenine Nucleotides/pharmacology Animals Dose-Response Relationship, Drug Kinetics L Cells/drug effects,metabolism Mice Oligonucleotides/pharmacology Oligoribonucleotides/pharmacology Poly I-C/pharmacology Protein Biosynthesis/drug effects RNA, Double-Stranded/genetics
Chemicals
Adenine Nucleotides Oligonucleotides Oligoribonucleotides RNA, Double-Stranded 2',5'-oligoadenylate Poly I-C
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Torrence P F
Imai J
Johnston M I
References (38)
38 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.10.5993
Published
1981-10-00
Pages
5993-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348963
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.10.5993 PMC Full Text View journal details
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