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PMID: 6950432 Published · ppublish English Journal Article

Specific cellular stimulation in the primary immune response: experimental test of a quantized model.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 3 ·1982-02-00 ·Pages 884-8

Dintzis RZ, Vogelstein B, Dintzis HM

Abstract

Dose-response and dose-suppression curves have been measured for the primary immune response in mice, in vivo and in vitro, by using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.

MeSH Terms
Acrylic Resins/immunology Animals Antibody Formation Antigens, T-Independent Dinitrobenzenes/immunology Dose-Response Relationship, Immunologic Haptens Kinetics Mice Models, Biological Receptors, Antigen/physiology
Chemicals
Acrylic Resins Antigens, T-Independent Dinitrobenzenes Haptens Receptors, Antigen polyacrylamide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dintzis R Z
Vogelstein B
Dintzis H M
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.3.884
Published
1982-02-00
Pages
884-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345857
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.79.3.884 PMC Full Text View journal details
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