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PMID: 6961423 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Evidence for a major cluster of lymphocyte differentiation antigens on murine chromosome 2.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 23 ·1982-12-00 ·Pages 7460-4

Meruelo D, Offer M, Rossomando A

Abstract

The region of chromosome 2 between H-13 and H-3 has been shown to contain loci coding for a variety of other alloantigens, including Ly-4 and the locus coding for beta 2-microglobulin. Herein we show that Ly-6 and Ly-11 are coded for by genes in a segment of chromosome 2 adjacent to the H-3-H-13 region and that this segment of chromosome also contains the tightly linked loci coding for antigens Ala-1, DAG, H9/25, H-30, Ly-8, and ThB. In addition, at least one locus (and probably more) affecting susceptibility to leukemia induction is found within this gene cluster.

MeSH Terms
Animals Antigens, Ly/genetics Antigens, Surface/genetics Chromosome Mapping Genes Genetic Linkage Lymphocytes/immunology Mice
Chemicals
Antigens, Ly Antigens, Surface
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Meruelo D
Offer M
Rossomando A
References (21)
21 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.23.7460
Published
1982-12-00
Pages
7460-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347359
Subset
IM
Grants
NCI NIH HHS · CA 22247 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.23.7460 PMC Full Text View journal details
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