Susceptibility to in vitro tolerance induction of adult B cells from mice with an X-linked B-cell defect.
Previous studies from this laboratory have indicated that the susceptibility to in vitro tolerance induction is restricted to B cells early in their development (12,14). In this study, a modification of the in vitro splenic focus technique was used to determine whether 2,4-dinitrophenyl (DNP)-specific splenic B cells from adult (CBA/N X DBA/2)F1 males are susceptible to in vitro tolerance induction. The results demonstrate that greater than 50% of the DNP-specific B cells in the adult F1 male are tolerizable and therefore immature by this criterion. Moreover, the findings define at least two subpopulation in adult CBA/N mice, one of which is tolerizable. These findings are consistent with the hypothesis that the lymphoid population in the adult CBA/N mouse is characteristic of a neonatal B-cell population.
14 references, click to expand
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The genetics of the immune response to a synthetic double-stranded RNA in a mutant CBA mouse strain.J Immunol. 1973 May;110(5):1396-401 PMID: 4121424
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The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.J Exp Med. 1975 May 1;141(5):1133-46 PMID: 47895
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X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.J Exp Med. 1975 Sep 1;142(3):637-50 PMID: 1080788
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Abnormal ratio of membrane immunoglobulin classes in mice with an X-linked B-lymphocyte defect.J Exp Med. 1975 Nov 1;142(5):1316-21 PMID: 1081577
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In vitro studies of the genetically determined unresponsiveness to thymus-independent antigens in CBA/N mice.J Immunol. 1976 Feb;116(2):301-4 PMID: 55435
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In vitro tolerance induction of neonatal murine B cells.J Exp Med. 1976 Jun 1;143(6):1327-40 PMID: 58052
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X-linked B-lymphocyte defect in CBA/N mice. III. Abnormal development of B-lymphocyte populations defined by their density of surface immunoglobulin.J Exp Med. 1976 Aug 1;144(2):507-18 PMID: 822117
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Studies on non-H-2-linked lymphocyte-activating determinants. II. Nonexpression of Mls determinants in a mouse strain with an X-linked B lymphocyte immune defect.J Immunol. 1976 Nov;117(5 Pt.2):1922-6 PMID: 62796
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Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.J Exp Med. 1977 Jan 1;145(1):10-20 PMID: 299766
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B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.J Exp Med. 1977 Jan 1;145(1):101-10 PMID: 299767
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In vitro tolerance induction of bone marrow cells: a marker for B cell maturation.J Immunol. 1977 Jun;118(6):2111-6 PMID: 405423
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Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.J Exp Med. 1977 Oct 1;146(4):1138-42 PMID: 302313
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Failure of CBA/N mice to respond to thymus-dependent and thymus-independent phosphorylcholine antigens.Cell Immunol. 1978 Jul;38(2):294-301 PMID: 354797
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