Home LiteratureArticle Details
PMID: 6972535 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Host restriction of Friend leukemia virus: gag proteins of host range variants.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 4 ·1981-04-00 ·Pages 2320-4

Duttagupta S, Soeiro R

Abstract

The host response to murine ecotropic leukemia viruses is mainly controlled by the mouse Fv-1 gene. This locus controls virus replication at an intracellular stage and prevents provirus integration. Biological studies suggest that the Fv-1 effector molecule recognizes at least one virion structural protein. We have produced host range variants of B-tropic Friend murine leukemia virus in order to study the primary structure of potential viral target proteins. Our results show that conversion of B-tropism to NB-tropism is associated with changes in the primary structure of three gag proteins--p15, p12, and p30. These results suggest that host range conversion is due to a recombinational event, presumably between the parental virus and an endogenous murine virus. They also open the possibility that p12 and p30 may be involved in host range restriction.

MeSH Terms
Amino Acid Sequence Friend murine leukemia virus/genetics Gene Products, gag Genes, Viral Peptide Fragments/analysis Recombination, Genetic Species Specificity Viral Proteins/genetics,physiology Virus Replication
Chemicals
Gene Products, gag Peptide Fragments Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Duttagupta S
Soeiro R
References (20)
20 references, click to expand
  1. Susceptibility to two strains of Friend leukemia virus in mice.
    Science. 1967 Jan 27;155(3761):461-2 PMID: 6015694
  2. Synthesis and circularization of N- and B-tropic retroviral DNA Fv-1 permissive and restrictive mouse cells.
    Proc Natl Acad Sci U S A. 1980 May;77(5):2994-8 PMID: 6248878
  3. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses.
    J Exp Med. 1971 Jun 1;133(6):1219-33 PMID: 4325132
  4. A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus.
    J Exp Med. 1971 Jun 1;133(6):1234-41 PMID: 4325133
  5. B-tropic Friend virus: a host-range pseudotype of spleen focus-forming virus (SFFV).
    Virology. 1973 Oct;55(2):363-70 PMID: 4742777
  6. Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses.
    J Virol. 1973 Sep;12(3):659-62 PMID: 4355863
  7. Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. V. Identification of a new murine viral protein, p15(E).
    J Virol. 1975 Jul;16(1):53-61 PMID: 166208
  8. Murine sarcoma virus pseudotypes acquire a determinant specifying N or B tropism from leukaemia virus during rescue.
    Nature. 1975 Jul 17;256(5514):223-5 PMID: 168499
  9. Phenotypic mixing between N- and B-tropic murine leukemia viruses: infectious particles with dual sensitivity to Fv-1 restriction.
    Cell. 1976 Mar;7(3):373-9 PMID: 181144
  10. Host restriction of Friend leukemia virus: synthesis and integration of the provirus.
    Proc Natl Acad Sci U S A. 1976 Jul;73(7):2356-60 PMID: 1065886
  11. Donation of N- or B-tropic phenotype to NB-tropic murine leukemia virus during mixed infections.
    J Virol. 1977 Jun;22(3):626-33 PMID: 195081
  12. RNase T1-resistant oligonucleotides of B-tropic murine leukemia virus from BALB/c and five of its NB-tropic derivatives.
    J Virol. 1977 Jul;23(1):188-95 PMID: 196102
  13. Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein.
    J Biol Chem. 1977 Sep 25;252(18):6510-5 PMID: 893422
  14. Evidence for recombination between N- and B-tropic murine leukemia viruses: analysis of three virion proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
    J Virol. 1977 Sep;23(3):700 PMID: 197267
  15. Effect of the Fv-1 locus in vivo: host range pseudotypes of murine sarcoma virus.
    J Natl Cancer Inst. 1978 Apr;60(4):875-80 PMID: 204797
  16. Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism.
    Proc Natl Acad Sci U S A. 1978 Sep;75(9):4170-4 PMID: 212738
  17. RNA sequencing provides evidence for allelism of determinants of the N-, B- or NB-tropism of murine leukemia viruses.
    Cell. 1979 Jan;16(1):43-50 PMID: 217545
  18. Mechanism of restriction of murine leukemia viruses varies between different strains of Fv-1n mice.
    Int J Cancer. 1979 Nov 15;24(5):600-7 PMID: 231017
  19. Effect of Fv-1 gene product on synthesis of linear and supercoiled viral DNA in cells infected with murine leukemia virus.
    J Virol. 1980 Jan;33(1):183-95 PMID: 6245227
  20. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.4.2320
Published
1981-04-00
Pages
2320-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319337
Subset
IM
Grants
NCI NIH HHS · 5-32CA09060 · United States
External Links
PubMed source DOI: 10.1073/pnas.78.4.2320 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2