HLA DR4 and rheumatoid arthritis in Japanese people.

Annals of the rheumatic diseases ·Vol. 40 ·No. 3 ·1981-06-00 ·Pages 299-302

Maeda H, Juji T, Mitsui H, Sonozaki H, Okitsu K

Abstract

Eighty-eight Japanese patients with rheumatoid arthritis and 104 normal Japanese persons were typed for HLA A, B, C, and DR antigens. The frequency of HLA DR4 was 70.5% in patients compared with 46.1% in normal controls (P less than 0.001). However, a sex difference in the frequency of HLA DR4 in patients was noted. HLA DR4 was found in 80.6% of male patients, which was highly significant compared with controls (P less than 0.0005), while only a borderline increase of 60.5% was found in female patients (P less than 0.05). In addition, the frequency of HLA DR2 was remarkably low in male patients. These suggest the possible heterogeneity of rheumatoid arthritis in Japanese.

MeSH Terms

Adult Aged Arthritis, Rheumatoid/immunology Asians Female HLA Antigens/analysis HLA-DR4 Antigen Histocompatibility Antigens Class II/analysis Humans Japan Male Middle Aged Sex Factors

Chemicals

HLA Antigens HLA-DR4 Antigen Histocompatibility Antigens Class II

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Maeda H

Juji T

Mitsui H

Sonozaki H

Okitsu K

References (17)

17 references, click to expand

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Article Info

Journal

Annals of the rheumatic diseases

Abbr.

Ann Rheum Dis

ISSN

0003-4967

DOI

10.1136/ard.40.3.299

Published

1981-06-00

Pages

299-302

Language

English

Region

England

NLM ID

0372355

PMCID

PMC1000766

Subset

External Links

PubMed source DOI: 10.1136/ard.40.3.299 PMC Full Text View journal details

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HLA DR4 and rheumatoid arthritis in Japanese people.

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