Home LiteratureArticle Details
PMID: 69730 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Biochemical and immunological characterization of the major envelope glycoprotein of bovine leukemia virus.

Journal of virology ·Vol. 23 ·No. 2 ·1977-08-00 ·Pages 443-7

Devare SG, Stephenson JR

Abstract

The major envelope glycoprotein of bovine leukemia virus was isolated by lectin-bound Sepharose and DEAE-cellulose column chromatography. This protein was shown to have a molecular weight of about 41,000 and to lack detectable immunological cross-reactivity with glycoproteins of other oncornaviruses. Sera obtained from 100% of cattle examined with clinically diagnosed lymphosarcoma contained high-titered antibody to 125I-labeled bovine leukemia virus glycoprotein, whereas sera from animals in a disease-free herd were antibody negative.

MeSH Terms
Animals Antibodies, Viral/analysis Cattle Cattle Diseases/immunology Epitopes Glycoproteins/analysis,immunology Leukemia Virus, Bovine/analysis,immunology Lymphoma, Non-Hodgkin/immunology,veterinary Molecular Weight Retroviridae/analysis Viral Proteins/analysis,immunology
Chemicals
Antibodies, Viral Epitopes Glycoproteins Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Devare S G
Stephenson J R
References (19)
19 references, click to expand
  1. PEDIGREE STUDIES IN BOVINE LYMPHOSARCOMA.
    Ann N Y Acad Sci. 1963 Nov 4;108:1193-202 PMID: 14081499
  2. Mason-Pfizer virus RNA genome: relationship to the RNA of morphologically similar isolates and other oncornaviruses.
    J Virol. 1976 Mar;17(3):705-12 PMID: 943573
  3. Immunological cross reactivity of Mason-Pfizer monkey virus with type C RNA viruses endogenous to primates.
    Nature. 1976 Jun 17;261(5561):609-11 PMID: 180419
  4. The purification of a gs antigen of the murine mammary tumor virus and its quantitation by radioimmunoassay.
    Virology. 1976 Nov;75(1):188-97 PMID: 185802
  5. Bovine lymphosarcoma: development of a radioimmunologic technique for detection of the etiologic agent.
    Science. 1976 Dec 24;194(4272):1428-30 PMID: 188129
  6. Structural proteins of mammalian oncogenic RNA viruses: multiple antigenic determinants of the major internal protein and envelope glycoprotein.
    J Virol. 1974 Jan;13(1):171-80 PMID: 4129838
  7. Structural proteins of mammalian oncogenic RNA viruses: murine leukemia virus neutralization by antisera prepared against purified envelope glycoprotein.
    J Virol. 1974 Jul;14(1):187-9 PMID: 4134470
  8. Biological expression of antigenic determinants of murine leukemia virus proteins gp69-71 and p30.
    J Virol. 1974 Nov;14(5):1274-80 PMID: 4139291
  9. Properties of mouse leukemia viruses. VIII. The major viral glycoprotein of Friend leukemia virus. Seroimmunological, interfering and hemagglutinating capacities.
    Virology. 1974 Dec;62(2):307-18 PMID: 4139810
  10. Immunological characterization of a low molecular weight polypeptide of murine leukemia virus.
    Virology. 1973 Jul;54(1):199-206 PMID: 4351609
  11. The polypeptide composition of mouse mammary tumor virus.
    Virology. 1974 Apr;58(2):387-95 PMID: 4362427
  12. Immunochemical characterization of two major polypeptides from murine mammary tumor virus.
    J Virol. 1974 Jun;13(6):1200-10 PMID: 4364896
  13. Polypeptides of the mouse mammary tumor virus. I. Characterization of two group-specific antigens.
    Virology. 1975 Apr;64(2):471-91 PMID: 49121
  14. Antigenic determinants of the 70,000 molecular weight glycoprotein of woolly monkey type C RNA virus.
    J Immunol. 1975 Oct;115(4):922-7 PMID: 51882
  15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  16. Characteristics of the major internal protein and RNA-dependent DNA polymerase of bovine leukaemia virus.
    J Gen Virol. 1975 Dec;29(3):305-14 PMID: 54405
  17. Bovine leukemia virus: an exogenous RNA oncogenic virus.
    Proc Natl Acad Sci U S A. 1976 Apr;73(4):1014-8 PMID: 57616
  18. Radiommunoassays for the 70,000-molecular-weight glycoproteins of endogenous mouse type C viruses: viral antigen expression in normal mouse tissues and sera.
    J Virol. 1976 Jun;18(3):933-41 PMID: 58081
  19. Seroepidemiological evidence for horizontal transmission of bovine C-type virus.
    Cancer Res. 1975 Oct;35(10):2714-6 PMID: 168965
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.23.2.443-447.1977
Published
1977-08-00
Pages
443-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC515848
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.23.2.443-447.1977 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2