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PMID: 6974868 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 7 ·1981-07-00 ·Pages 4566-70

Shackelford DA, Mann DL, van Rood JJ, Ferrara GB, Strominger JL

Abstract

Some human B-lymphoblastoid cell lines are shown to express at least two types of Ia-like antigens. One antigen is defined by alloantisera to HLA-DR, and the other antigen is defined by alloantisera and a monoclonal antibody to the specificities DC1, MT1 (MB1), and LB12, which are in linkage disequilibrium with HLA-DR. The subunits of the DC1 molecule differ from those of the DR molecule. The light chains of both molecules are structurally polymorphic.

MeSH Terms
B-Lymphocytes/immunology Electrophoresis, Polyacrylamide Gel HLA Antigens/analysis HLA-DR Antigens Histocompatibility Antigens Class II/analysis Humans Macromolecular Substances Molecular Weight Polymorphism, Genetic
Chemicals
HLA Antigens HLA-DR Antigens Histocompatibility Antigens Class II Macromolecular Substances
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Shackelford D A
Mann D L
van Rood J J
Ferrara G B
Strominger J L
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23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.7.4566
Published
1981-07-00
Pages
4566-70
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319833
Subset
IM
Grants
NIAID NIH HHS · AI 10736 · United States
External Links
PubMed source DOI: 10.1073/pnas.78.7.4566 PMC Full Text View journal details
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