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PMID: 6977010 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells.

The Journal of experimental medicine ·Vol. 155 ·No. 2 ·1982-02-01 ·Pages 611-6

Clark AF, Capra JD

Abstract

A ubiquitous nonimmunoglobulin molecule that binds p-azobenzenearsonate (ABA) has been detected in the cytoplasm of several murine cell lines, including T cell hybridomas as well as in normal liver and spleen. Similar to many recently described antigen-specific T cell factors, this ABA-binding protein has a 62,000 mol wt, and, when analyzed by direct binding, the molecule reacts with several different rabbit anti-idiotypic antisera specific to the ABA system. The presence of this antigen-specific, "idiotype positive" molecule in many different cells indicates that it is not an important immunoregulatory molecule.

MeSH Terms
Animals Azo Compounds/immunology Binding Sites Carrier Proteins/metabolism Cross Reactions Hybridomas/immunology Immunoglobulin Idiotypes/immunology Immunoglobulins/immunology Mice Mice, Inbred A Rabbits T-Lymphocytes/immunology p-Azobenzenearsonate/immunology,metabolism
Chemicals
Azo Compounds Carrier Proteins Immunoglobulin Idiotypes Immunoglobulins p-Azobenzenearsonate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Clark A F
Capra J D
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21 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.155.2.611
Published
1982-02-01
Pages
611-6
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186592
Subset
IM
Grants
NIAID NIH HHS · AI12127 · United States
NIAID NIH HHS · AI17909 · United States
NCI NIH HHS · CA09082 · United States
External Links
PubMed source DOI: 10.1084/jem.155.2.611 PMC Full Text View journal details
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