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PMID: 6985463 Published · ppublish English Journal Article

Regional assignment of the gene locus for steroid sulfatase.

Human genetics ·Vol. 54 ·No. 2 ·1980-00-00 ·Pages 201-4

Müller CR, Westerveld A, Migl B, Franke W, Ropers HH

Abstract

The gene locus for steroid sulfatase, deficiency of which causes X-linked ichthyosis, is assigned to Xp11 leads to Xpter by analysis of 24 man-Chinese hamster somatic cell hybrids. High steroid sulfatase activity in a hybrid clone having retained only part of Xq is explained by demonstration of an additional late-replicating human X chromosome. This observation confirms previous evidence for noninactivation of the STS locus.

MeSH Terms
Animals Chromosome Mapping Clone Cells Cricetinae Cricetulus Female Humans Hybrid Cells In Vitro Techniques Sex Chromosomes/ultrastructure Steryl-Sulfatase Sulfatases/genetics X Chromosome/ultrastructure
Chemicals
Sulfatases Steryl-Sulfatase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Müller C R
Westerveld A
Migl B
Franke W
Ropers H H
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20 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00278972
Published
1980-00-00
Pages
201-4
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00278972 View journal details
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