Home LiteratureArticle Details
PMID: 700701 Published · ppublish English Journal Article

Preferential X inactivation in human placenta membranes: is the paternal X inactive in early embryonic development of female mammals?

Human genetics ·Vol. 43 ·No. 3 ·1978-09-19 ·Pages 265-73

Ropers HH, Wolff G, Hitzeroth HW

Abstract

In placenta membranes of newborn girls carrying electrophoretically distinguishable G6PD alleles, the maternally derived isozyme is expressed preferentially. This phenomenon cannot be explained by allelic differences in enzyme activity or by somatic selection directed against cells with particular G6PD phenotypes. Instead, it may be that in this tissue X inactivation is nonrandom. Preferential expression of the maternal X chromosome, as has been shown in marsupials and in extraembryonic membranes of rodents and now in man, may reflect the state of activity of the X chromosomes in the early stages of female embryonic development.

MeSH Terms
Female Glucosephosphate Dehydrogenase/genetics Humans Infant, Newborn Isoenzymes/genetics Male Mosaicism Phenotype Placenta/enzymology,ultrastructure Pregnancy Sex Chromosomes Sex Factors X Chromosome
Chemicals
Isoenzymes Glucosephosphate Dehydrogenase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ropers H H
Wolff G
Hitzeroth H W
References (28)
28 references, click to expand
  1. X inactivation, differentiation, and DNA methylation.
    Cytogenet Cell Genet. 1975;14(1):9-25 PMID: 1093816
  2. Non-random late replication of X chromosomes in mules and hinnies.
    Nature. 1971 Jul 30;232(5309):315-9 PMID: 5094835
  3. Non-random inactivation of X chromosome in the rat yolk sac.
    Nature. 1976 Aug 12;262(5569):580-1 PMID: 958416
  4. Expression of the mammalian X chromosome before and after fertilization.
    Science. 1972 Mar 31;175(4029):1467-8 PMID: 5013677
  5. X chromosome inactivation studied by injection of a single cell into the mouse blastocyst.
    Nature. 1971 Jun 11;231(5302):385-6 PMID: 4931003
  6. Inactivation system of the mammalian X chromosome.
    Proc Natl Acad Sci U S A. 1973 Jan;70(1):195-9 PMID: 4509651
  7. X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro.
    Nature. 1978 Jan 26;271(5643):329-33 PMID: 563984
  8. Glyoxalase I polymorphism in South African Bantu-speaking negroids.
    Hum Genet. 1977 Sep 22;38(2):223-6 PMID: 908569
  9. Chromosome imprinting and the mammalian X chromosome.
    Nature. 1975 Jan 17;253(5488):165-8 PMID: 1089205
  10. Mammalian X-chromosome inactivation.
    Adv Hum Genet. 1976;7:99-140 PMID: 797247
  11. Gene activation during early development of mammals.
    Humangenetik. 1972;15(2):99-118 PMID: 4558858
  12. Preferential expression of the maternally derived X chromosome in the mouse yolk sac.
    Cell. 1977 Dec;12(4):873-82 PMID: 597862
  13. Two functional X chromosomes in human fetal oocytes.
    Exp Cell Res. 1973 Dec;82(2):464-6 PMID: 4765252
  14. Tentative evidence for 3--4 haematopoetic stem cells in man.
    Hum Genet. 1977 Feb 11;35(2):175-83 PMID: 844863
  15. Cytological and biochemical correlation of late X-chromosome replication and gene inactivation in the mule.
    Proc Natl Acad Sci U S A. 1971 Mar;68(3):544-8 PMID: 5276759
  16. Evidence for two functional X chromosomes in human oocytes.
    Cell Differ. 1972 Oct;1(4):215-8 PMID: 4670884
  17. Non-random X chromosome expression in female mules and hinnies.
    Nature. 1971 Jul 30;232(5309):312-5 PMID: 5094834
  18. Directed genetic change model for X chromosome inactivation in eutherian mammals.
    Nature. 1971 Apr 2;230(5292):292-4 PMID: 5549404
  19. The temporal appearance of sex chromatin and of the late-replicating X chromosome in blastocysts of the domestic rabbit.
    Cytogenetics. 1969;8(3):219-37 PMID: 5802538
  20. Unusually long survival in a case of full triploidy of maternal origin.
    Hum Genet. 1977 Sep 22;38(2):147-55 PMID: 908561
  21. On the genetic interpretation of the 6-phosphogluconate-dehydrogenase-isozymes in man.
    Vox Sang. 1970 Mar;18(3):244-50 PMID: 5463030
  22. X-chromosome inactivation and developmental patterns in mammals.
    Biol Rev Camb Philos Soc. 1972 Jan;47(1):1-35 PMID: 4554151
  23. Expression of alpha-galactosidase in preimplantation mouse embryos.
    Nature. 1977 Jun 30;267(5614):838-9 PMID: 895843
  24. Dosage compensation for an X-linked gene in pre-implantation mouse embryos.
    Nature. 1977 Dec 15;270(5638):599-601 PMID: 563522
  25. Differentiation of X chromosomes in early female mouse embryos.
    Exp Cell Res. 1974 May;86(1):127-35 PMID: 4133904
  26. The role of X-chromosome inactivation during spermatogenesis (Drosophila-allocycly-chromosome evolution-male sterility-dosage compensation).
    Proc Natl Acad Sci U S A. 1972 Jan;69(1):182-6 PMID: 4621547
  27. Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse.
    Nature. 1975 Aug 21;256(5519):640-2 PMID: 1152998
  28. X chromosome inactivation in diploid parthenogenetic mouse embryos.
    Nature. 1978 Feb 9;271(5645):547-9 PMID: 622189
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00278833
Published
1978-09-19
Pages
265-73
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00278833 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2