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PMID: 7012131 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mutations to tolerance and resistance to pesticin and colicins in Escherichia coli phi.

Journal of bacteriology ·Vol. 146 ·No. 2 ·1981-05-00 ·Pages 506-11

Ferber DM, Fowler JM, Brubaker RR

Abstract

The universal colicin-indicator strain Escherichia coli phi, unlike E. coli strain K-12, is sensitive to pesticin, a bacteriocin produced by wild-type Yersinia pestis. Eleven distinct phenotypes of E. coli phi mutants were obtained by selection for insensitivity to pesticin, group B colicins, the group A colicin S4, or coliphage T5. Representative isolates from eight of these classes closely resembled resistant receptor mutants (Cir-, Fep-, and TonA-) or tolerant mutants (TonB-, ExbB-, ExbC-, Ivt-, and Cmt-) described in Escherichia coli K-12. The remainder were unique; of these, one resembled TonB- but was also tolerant to colicin S4 (TonB/S4-), and the others exhibited specific resistance to either colicin S4 (Sfr-) or to pesticin (Psr-). All receptor mutants except Psr- remained sensitive to pesticin, whereas TonB/S4, TonB-, ExbB-, and ExbC- isolates were highly tolerant to this bacteriocin.

MeSH Terms
Bacteriocins Colicins/pharmacology Drug Resistance, Microbial Drug Tolerance Escherichia coli/drug effects,genetics Mutation Yersinia pestis
Chemicals
Bacteriocins Colicins Pesticin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ferber D M
Fowler J M
Brubaker R R
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37 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.146.2.506-511.1981
Published
1981-05-00
Pages
506-11
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC216992
Subset
IM
Grants
NIAID NIH HHS · AI 13590 · United States
External Links
PubMed source DOI: 10.1128/jb.146.2.506-511.1981 PMC Full Text View journal details
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