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PMID: 7041122 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The two yeast histone H2A genes encode similar protein subtypes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 5 ·1982-03-00 ·Pages 1484-7

Choe J, Kolodrubetz D, Grunstein M

Abstract

The sequences of the two histones H2A genes in the yeast Saccharomyces cerevisiae have been determined. These genes encode two histone H2A subtypes which are 131 amino acids in length but differ at 2 amino acid positions: an Ala leads to Thr and a Thr leads to Ala change at positions 124 and 125. Thus, the two histone H2A subtypes have identical amino acid compositions. The coding regions of the two H2A genes are homologous at 369 of 393 bases (94%), with all but 2 of the 24 changes being silent. There is only 30% homology in the 5' flanking sequences of the two H2A genes. Like other eukaryotic histone genes, the yeast H2A genes are not interrupted by intervening sequences. When the yeast H2A histones are compared to those from other eukaryotes, there is at least 80% homology in amino acid sequence.

MeSH Terms
Amino Acid Sequence Base Sequence Biological Evolution Codon Genes Histones/genetics Saccharomyces cerevisiae/genetics
Chemicals
Codon Histones
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Choe J
Kolodrubetz D
Grunstein M
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.5.1484
Published
1982-03-00
Pages
1484-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345998
Subset
IM
Grants
NCI NIH HHS · CA-14764 · United States
Databases
GENBANK
J01325, J01326
External Links
PubMed source DOI: 10.1073/pnas.79.5.1484 PMC Full Text View journal details
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