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PMID: 7046453 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Fibrin deposits in Hodgkin's disease.

The American journal of pathology ·Vol. 108 ·No. 1 ·1982-07-00 ·Pages 119-29

Harris NL, Dvorak AM, Smith J, Dvorak HF

Abstract

Fibrin deposits were observed in the involved lymph nodes and/or spleens of 15 patients with Hodgkin's disease by specific immunofluorescence and by electron microscopy. Two basic patterns of fibrin deposition were observed: 1) intercellular deposits, chiefly associated with nonneoplastic-appearing lymphoid cells and 2) deposits associated with the collagen fibers of young connective tissue. In addition, coarse fibrin deposits were observed in areas of necrosis, presumably a non-specific finding. Fibronectin was also observed in intercellular areas, but staining was less intense than for fibrin. Fibrin deposits were also observed in 3 of 6 cases of non-Hodgkin's lymphoma, indicating that the finding is not an exclusive feature of Hodgkin's disease. The pathogenesis and possible significance of fibrin deposition in Hodgkin's disease are related to earlier observations of activation of the coagulation system on neoplasia and cell-mediated immunity and to the possible role of fibrin, fibronectin, and their breakdown products in angiogenesis and fibroplasia.

MeSH Terms
Collagen/metabolism Connective Tissue/metabolism Fibrin/analysis,metabolism Fibronectins/analysis Fluorescent Antibody Technique Hodgkin Disease/metabolism Humans Lymph Nodes/metabolism,ultrastructure Lymphoma/metabolism Microscopy, Electron Spleen/metabolism,ultrastructure
Chemicals
Fibronectins Fibrin Collagen
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Harris N L
Dvorak A M
Smith J
Dvorak H F
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36 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1982-07-00
Pages
119-29
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1916024
Subset
IM
Grants
NCI NIH HHS · CA 09216 · United States
NCI NIH HHS · CA 28471 · United States
External Links
PubMed source PMC Full Text View journal details
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