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PMID: 7054119 Published · ppublish English Comparative Study Journal Article

Correlation between in vivo anti-Pseudomonas and anti-Candida activities and clearance of carbon by the reticuloendothelial system for various muramyl dipeptide analogs, using normal and immunosuppressed mice.

Infection and immunity ·Vol. 35 ·No. 1 ·1982-01-00 ·Pages 105-10

Fraser-Smith EB, Waters RV, Matthews TR

Abstract

A linear correlation coefficient analysis, comparing in vivo anti-infective and reticuloendothelial stimulating activity of several different analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) suggests that the macrophage is an important target cell for these immunomodulating compounds. The increase in protection against infections of Candida albicans or Pseudomonas aeruginosa in normal or immunosuppressed mice after treatment with 18 different glycopeptides was found to correlate with the degree of clearance of colloidal carbon particles from the blood by the reticuloendothelial system after treatment with the same muramyl dipeptide analogs. The compound which gave the greatest protection in all four assays was N-acetylmuramyl-L-alpha-aminobutyryl-D-isoglutamine followed by N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine. Both analogs were better than the parent muramyl dipeptide. Whether macrophage stimulation alone is responsible for the anti-infective properties of these compounds has not yet been determined.

MeSH Terms
Acetylmuramyl-Alanyl-Isoglutamine/pharmacology Adjuvants, Immunologic/pharmacology Animals Candidiasis/immunology Glycopeptides/pharmacology Immunosuppression Therapy Macrophages/immunology Mice Phagocytosis/drug effects Pseudomonas Infections/immunology Structure-Activity Relationship
Chemicals
Adjuvants, Immunologic Glycopeptides Acetylmuramyl-Alanyl-Isoglutamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fraser-Smith E B
Waters R V
Matthews T R
References (28)
28 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.35.1.105-110.1982
Published
1982-01-00
Pages
105-10
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC351002
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.35.1.105-110.1982 PMC Full Text View journal details
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