Pharmacological evaluation of cefaclor in volunteers.

Antimicrobial agents and chemotherapy ·Vol. 14 ·No. 3 ·1978-09-00 ·Pages 454-6

Hodges GR, Liu C, Hinthorn DR, Harms JL, Dworzack DL

Abstract

The plasma and urine concentrations of cefaclor were measured after oral administration of single and multiple doses to volunteers. Cefaclor was rapidly absorbed, rapidly excreted in the urine, well tolerated without toxicity, and failed to accumulate in the plasma with chronic dosing.

MeSH Terms

Adult Cephalosporins/metabolism,toxicity Female Half-Life Humans Male Middle Aged

Chemicals

Cephalosporins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Hodges G R

Liu C

Hinthorn D R

Harms J L

Dworzack D L

References (6)

6 references, click to expand

In vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.
Antimicrob Agents Chemother. 1977 Sep;12(3):442-3 PMID: 907337
Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.
Antimicrob Agents Chemother. 1977 Mar;11(3):470-4 PMID: 301005
In vitro activities of five oral cephalosporins against aerobic pathogenic bacteria.
Antimicrob Agents Chemother. 1977 Nov;12(5):609-13 PMID: 921258
In vitro studies with cefaclor, a new oral cephalosporin.
Antimicrob Agents Chemother. 1977 Oct;12(4):490-7 PMID: 921244
In vitro susceptibility studies with cefaclor and cephalexin.
Antimicrob Agents Chemother. 1977 Aug;12(2):290-2 PMID: 900924
Comparative pharmacology of cefaclor and cephalexin.
Antimicrob Agents Chemother. 1977 Aug;12(2):157-62 PMID: 900915

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.14.3.454

Published

1978-09-00

Pages

454-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC352480

Subset

External Links

PubMed source DOI: 10.1128/AAC.14.3.454 PMC Full Text View journal details

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